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Artículo
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome ...
Tesis Doctoral
Elongación transcripcional en Saccharomyces Cerevisiae influencia en el control del ciclo celular y nuevas herramientas para su estudio "in vivo"
(2007)
La transcripción es el proceso mediante el cual la información genética, contenida en el DNA, es expresada en forma de RNA. La mayor parte de los genes eucarióticos, tanto aquellos que codifican proteínas como la mayoría ...
Artículo
Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. The use of new techniques based on tandem affinity purification (TAP) and chromatin immunoprecipitation ...
Artículo
CDK targets Sae2 to control DNA-end resection and homologous recombination
(Nature Publishing Group, 2008)
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR)1. HR is the most accurate DSB repair mechanism but is generally restricted to ...
Artículo
Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms
(BMC, 2009)
Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae that is positioned close to the centrosome in a microtubule-dependent manner. How this organisation is ...