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Mostrando ítems 1-10 de 25
Artículo
Surface-Active Properties of Lipophilic AntioxidantsTyrosol and Hydroxytyrosol Fatty Acid Esters: A PotentialExplanation for the Nonlinear Hypothesis of the AntioxidantActivity in Oil-in-Water Emulsions
(American Chemical Society, 2001)
Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters in fish oil-in-water emulsions, where a maximum of antioxidant efficiency appeared for hydroxytyrosol ...
Artículo
Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents
(American Chemical Society, 2010-10-28)
There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring polyphenol resveratrol exerts anti-inflammatory properties. However, its rapid metabolism diminishes ...
Artículo
Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
(Elsevier, 2017)
The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate ...
Artículo
Metabolites and tissue distribution of resveratrol in the pig
(Wiley-Blackwell, 2011-08)
Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans. Methods and ...
Artículo
Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents
(Elsevier, 2016)
Trypanosomiasis and leishmaniasis keep being a real challenge for health and development of African countries. Existing treatments have considerable side effects and increase resistance of the parasites. We have measured ...
Artículo
Apolar carbohydrates as DNA capping agents
(Royal Society of Chemistry, 2012)
Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. Here we present an apolar version of glucose and cellobiose as new capping agents that stack on ...
Artículo
Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites
(Wiley-Blackwell, 2016)
Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability and rapid metabolism to its glucuronate and sulfate conjugates has opened a debate on the mechanisms ...
Artículo
Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
(Royal Society of Chemistry, 2017)
Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. ...
Artículo
Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells
(Royal Society of Chemistry, 2016)
The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) to act as antioxidants counteracting the pro-oxidant effect of oxidized cholesterol in intestinal ...
Artículo
pH-Responsive Polymeric Nanoparticles as Drug Delivery Systems
(JSciMed Central, 2017-04)
Micelles are excellent devices to be used as controlled drug delivery systems since they exhibit the ability to protect the drug or encapsulated substance from the routes of degradation until they reach the site of action: ...