Química Orgánica y Farmacéutica: Envíos recientes
Mostrando ítems 61-80 de 234
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Tesis Doctoral
Diseño y síntesis de nuevos agentes quimioterápicos: receptores acoplados a proteína G (NK1 y CB2) y factores de transcripción (Nrf2 y STAT3) como dianas terapéuticas
(2022-12-02)El cáncer es una enfermedad de gran impacto sanitario, económico y social en la población, para la que aún no se dispone ...
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Artículo
Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. In vitro antiviral activity evaluation against Zika and Dengue viruses
(Elsevier, 2023)Since 2011 Direct Acting antivirals (DAAs) drugs targeting different non-structural (NS) viral proteins (NS3, NS5A or NS5B ...
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Artículo
Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices
(Elsevier, 2022)Chronic infection as a result of bacterial biofilm formation on implanted medical devices is a major global healthcare ...
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Artículo
Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)The spread of antibiotic resistance among human and animal pathogens is one of the more significant public health concerns. ...
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Artículo
Hábitos y normas de seguridad recomendadas en un laboratorio de entorno químico
(Asociación Profesional de Gestores de Emergencias y Seguridad, 2008)Las nuevas normativas que la Legislación impone relativas a los hábitos saludables y de seguridad que deben cumplirse en ...
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Artículo
Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
(Wiley, 2018)Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ...
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Patente
Neoglicolipidos, sus agregados con nanotubos de carbono, procedimiento de obtencion y aplicaciones
(Oficina Española de Patentes y Marcas , 2009-11-23)La presente invención se refiere a un glicolípido de fórmula (I) en la que R es un carbohidrato seleccionado entre un ...
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Artículo
Molecular bottom-up approaches for the synthesis of inorganic and hybrid nanostructures
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Chemical routes for the synthesis of nanostructures are fundamental in nanoscience. Among the different strategies for the ...
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Artículo
Immunomodulatory Effects of (R)-Sulforaphane on LPS-Activated Murine Immune Cells: Molecular Signaling Pathways and Epigenetic Changes in Histone Markers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the ...
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Artículo
Benzothiazole Derivatives Endowed with Antiproliferative Activity in Paraganglioma and Pancreatic Cancer Cells: Structure–Activity Relationship Studies and Target Prediction Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)The antiproliferative effects played by benzothiazoles in different cancers have aroused the interest for these molecules ...
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Artículo
A multidisciplinary perspective on the latest trends in artificial cartilage fabrication to mimic real tissue
(Elsevier, 2022-12)Articular cartilage (AC) has a low ability for endogenous repair, and current treatments are not completely efficient in ...
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Artículo
Magnetic Nanoparticles as MRI Contrast Agents
(Springer, 2020)Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic ...
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Artículo
Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation
(American Chemical Society, 2010)Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides ...
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Artículo
Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations
(Springer Nature, 2011)Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or ...
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Artículo
Apolar carbohydrates as DNA capping agents
(Royal Society of Chemistry, 2012)Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. ...
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Artículo
Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End
(Wiley-Blackwell, 2013)Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, ...
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Artículo
Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
(Elsevier, 2013)Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been ...
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Artículo
Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells
(Royal Society of Chemistry, 2016)The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) ...
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Artículo
Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models
(American Chemical Society, 2016)Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of ...
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Artículo
Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites
(Wiley-Blackwell, 2016)Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability ...