Now showing items 1-5 of 5

    • Article
      Icon

      Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells 

      Villanueva-Paz, Marina; Cordero, Mario D.; Pavón, Ana Delgado; Castejón Vega, Beatriz; Cotán, David; De la Mata, Mario; Oropesa-Ávila, Manuel; Alcocer-Gómez, Elísabet; Muntané Relat, Jordi; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio (2016-08-07)
      Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the ...
    • Article
      Icon

      Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria 

      González Domínguez, Álvaro; Montañez Martínez, Raúl; Castejón Vega, Beatriz; Núñez Vasco, Jessica; Lendines Cordero, Débora; Wang, Chun; Mbalaviele, Gabriel; Navarro Pando, José Manuel; Alcocer-Gómez, Elísabet; Cordero Morales, Mario David (WILEY-BLACKWELL, 2021)
      Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). ...
    • Article
      Icon

      Inhibition of the NLRP3 inflammasome prevents ovarian aging 

      Navarro Pando, José Manuel; Alcocer-Gómez, Elísabet; Castejón Vega, Beatriz; Navarro Villarán, Elena; Condés Hervás, Mónica; Mundi Roldán, María; Muntané Relat, Jordi; Pérez Pulido, Antonio J.; Bullon, Pedro; Wang, Chun; Hoffman, Hal M.; Sanz Montero, Alberto; Mbalaviele, Gabriel; Ryffel, Bernhard; Cordero, Mario D. (American Association for the Advancement of Science, 2021)
      Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of ...
    • Article
      Icon

      L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation 

      Castejón Vega, Beatriz; Rubio Valle, Alejandro; Pérez Pulido, Antonio J.; Quiles Morales, José Luis; Lane, Jon D.; Fernández Domínguez, Beatriz; Alcocer-Gómez, Elísabet; Cordero, Mario D. (MDPI, 2021)
      Aims: Tay–Sachs and Sandhoff diseases (GM2 gangliosidosis) are autosomal recessive disorders of lysosomal function that ...
    • Article
      Icon

      NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice. 

      Marín-Aguilar, Fabiola; Lechuga‐Vieco, A.V.; Alcocer-Gómez, Elízabet; Castejón Vega, Beatriz; Lucas, Javier; Garrido, Carlos; Peralta García, Alejandro; Pérez‐Pulido, Antonio J.; Varela‐López, Alfonso; Bullon, Pedro; Cordero, Mario D. (John Wiley & Sons Ltd and The Anatomical Society, 2019-09-23)
      While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely ...