Listar Fisiología Médica y Biofísica por agencia financiadora "Junta de Andalucía"
Mostrando ítems 1-18 de 18
-
Artículo
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
-
Artículo
A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity
(Cell Press, 2023-05-13)Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical ...
-
Artículo
A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function
(Elsevier, 2015-09-03)Neuroligins (NLs) are cell-adhesion proteins that regulate synapse formation and function. Neuroligin 1 (NL1) promotes the ...
-
Artículo
Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy
(Public Library of Science, 2019-01-09)In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by ...
-
Artículo
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
(Springer, 2021)Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
-
Artículo
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
(Wiley, 2018)Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded ...
-
Artículo
Ketotifen is a microglial stabilizer by inhibiting secretory vesicle acidification
(Elsevier, 2023)Aims: Microglia survey the brain environment by sensing alarm signals to provide the first line of defense against injury ...
- Otros
-
Artículo
MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms
(Massachusetts Medical Society, 2005)JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were ...
-
Artículo
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
-
Artículo
Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
(Society for Neuroscience, 2018-01-24)Proteolytic processing of synaptic adhesion components can accommodate the function of synapses to activity-dependent ...
-
Artículo
Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis
(Elsevier, 2022-11)The isolation of synaptoneurosomes (SNs) represents a useful means to study synaptic events. However, the size and density ...
-
Artículo
Research facilities and highlights at the Centro Nacional de Aceleradores (CNA)
(Springer, 2021)The Centro Nacional de Aceleradores is a user-oriented accelerator facility in Seville, Spain. Its main facilities are a ...
-
Ponencia
Single restraint stress sensitizes acute chewing movements induced by haloperidol, but not if the 5-HT agonist 8-OH-DPAT is given prior to stress
(Elsevier, 1997)The objective of this study was two-fold: ( i) to analyze behavioral sensitization to haloperidol 2 weeks after single ...
-
Artículo
Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
-
Artículo
The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
(Frontiers Media, 2018-03-21)Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ...
-
Artículo
The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGF and Hippo pathways
(OXFORD UNIV PRESS, 2022)High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation ...
-
Artículo
Trasplante de células naturales "dopaminotróficas" nuevo concepto terapeútico antiparkinsoniano
(Viguera, 2003)Aim and method. Parkinson's disease is caused by the degeneration of dopamineric neurons of substantia nigra projecting ...