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Artículo
Fluorescent calixarene-schiff as a nanovehicle with biomedical purposes
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-07-14)
Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. ...
Tesis Doctoral
Utilidad clínica de los estudios genéticos y técnicas de secuenciación masiva en los pacientes con diabetes mellitus. Estudio retrospectivo en área sanitaria sur de Sevilla
(2022-06-07)
Introducción e hipótesis El desarrollo en los últimos años de los estudios genéticos y las técnicas de secuenciación masiva o ensayos de nueva generación (Next Generation Sequencing-NGS) ha permitido el análisis simultáneo ...
Artículo
Obesity and Risk for Lymphoma: Possible Role of Leptin
(MDPI, 2022-12-08)
Obesity, which is considered a pandemic due to its high prevalence, is a risk factor for many types of cancers, including lymphoma, through a variety of mechanisms by promoting an inflammatory state. Specifically, over the ...
Artículo
A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice
(MDPI AG, 2022)
Anxiety is the most prevalent psychiatric disorder worldwide, causing a substantial economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments may cause important side effects and ...
Artículo
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
(MDPI AG, 2022)
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases ...
Artículo
Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients
(NATL ACAD SCIENCES, 2022)
Chemokine receptor nanoscale organization at the cell membrane is orchestrated by the actin cytoskeleton and influences cell responses. Using single-particle tracking analysis we show that CXCR4R334X, a truncated mutant ...
Artículo
Editorial: Nanoparticle-Mediated Signaling Rewiring and Reprogramming of Immune Responses
(FRONTIERS MEDIA SA, 2022)
Recent advances on the molecular mechanisms that control immune cells are at the core of the development of better immunomodulatory therapies. For example, these mechanisms may enable T cell manipulation interventions ...
Artículo
Moderate beer consumption and metabolic health: A comprehensive review from the lipoprotein perspective
(Elsevier Science BV, 2022)
effects on our health. Regarding cardiovascular disease, research needs to consider the amount consumed but also drinking thresholds, frequency of drinking, age and gender of consumers, lifestyle, or non-alcoholic com ...
Artículo
Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients
(MDPI, 2022-09-09)
Background and objective: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, obesity, and insulin resistance, which leads to subfertility. PCOS is the ...
Artículo
Hemp protein hydrolysates modulate inflammasome-related genes in microglial cells
(MDPI, 2022-12-27)
A prolonged inflammatory response can lead to the development of neurodegenerative diseases such as Alzheimer’s disease. Enzymatic hydrolysis is a sustainable way to increase the value of protein sources by obtaining ...