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Tesis Doctoral
Artículo
Dietary fatty acids and lipoproteins on progression of age-related macular degeneration
(CSIC, 2017)
Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. ...
Artículo
Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
(Elsevier, 2017)
The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate ...
Artículo
Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
(Royal Society of Chemistry, 2017)
Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. ...
Artículo
Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
(Frontiers Media, 2017)
In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and motor neurone disease (MND) have two factors in common: (i) advancing age as the single ...
Tesis Doctoral
Contribución de un desayuno de tipo mediterráneo a la prevención del desarrollo de aterosclerosis en individuos obesos
(2017-10-23)
INTRODUCCIÓN: La obesidad es considerada en la actualidad una enfermedad inflamatoria crónica de bajo grado, relacionada con un desorden en el metabolismo postprandial de los lípidos que, a largo plazo, acaba generando ...
Artículo
Dietary fatty acids on aortic root calcification in mice with metabolic syndrome
(Royal Society of Chemistry, 2017)
Metabolic syndrome (MetS) is associated with obesity, dyslipidemia, type 2 diabetes, and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in ...
Artículo
Newborn Screening for Primary T- and B-Cell Immune Deficiencies—A Prospective Study in Andalucía
(MDPI, 2017)
Background: Quantification of T-cell-receptor-excision circles (TRECs) and kappa-deleting-recombination-excision circles (KRECs) from dried blood spots (DBS) allows detection of neonates with severe T-cell and/or B-cell ...
Tesis Doctoral
Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones
(2017-05-22)
This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. The first part of this work was to study the impact of extracellular aSyn priming on the ...
Artículo
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
(Wolters Kluwer Health, 2017)
Objective-Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage ...