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Artículo
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death
(IOS Press, 2016)
Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ...
Tesis Doctoral
Prevalencia de factores de riesgo cardiovascular asociados a marcadores genéticos en población andaluza
(2016-02-04)
Introducción: Las enfermedades cardiovasculares siguen siendo a día de hoy una de las más importantes causas de morbimortalidad en todo el mundo y también en los países de nuestro entorno.Los principales factores de riesgo ...
Tesis Doctoral
Esclerosis lateral amiotrófica: investigaciones en el modelo sod1g93a y correlaciones de interés clínico
(2016-06-03)
La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa, incurable y de carácter fatal en un plazo de 3-5 años desde su diagnóstico. Esta enfermedad se caracteriza por la degeneración progresiva de ...
Artículo
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels seem to have a role modulating the growth of these tumours. Sam68 is an RNA-binding protein with ...
Tesis Doctoral
Eficacia de los marcadores bioquímicos para el diagnóstico y pronóstico de la artritis reumatoide en pacientes que acuden a una consulta de atención especializada
(2016-01-29)
La Artritis Reumatoide (AR) es una enfermedad autoinmune sistémica, inflamatoria y crónica que afecta al 0,5-1% de la población. Se asocia a daño articular severo y provoca un grave sufrimiento a la persona que la padece, ...
Artículo
Olive oil and postprandial hyperlipidemia: Implications for atherosclerosis and metabolic syndrome
(Royal Society of Chemistry, 2016)
Olive oil is the primary source of fat in the Mediterranean diet, which is associated with a significant improvement in health status, as measured by reduced mortality from several chronic diseases. The current pandemic ...
Artículo
The Immune System in Foetal Death After a Spider Bite: Case Report with Literature Review
(Omics Publishing Group, 2016-11)
Loxoscelism is caused by the bite of a spider belonging to any of the Loxosceles species. We analyse the case of a pregnant woman, 35 weeks into gestation, who was accidentally bitten by a Loxosceles rufescens, in June ...
Artículo
The role of melatonin in autoimmune and atopic diseases
(AIMS Press, 2016)
Melatonin is the main secretory product synthesized and secreted by the pineal gland during the night. Melatonin is a pleitropic molecule with a wide distribution within phylogenetically distant organisms and has a great ...
Artículo
Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome
(Elsevier, 2016)
We aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination ...
Artículo
Possible involvement of the inhibition of NF-kβ factor in anti_inflammatory actions that melatonin exert on mast cells
(2016-01-08)
Melatonin is a molecule endogenously produced in a wide variety of immune cells, including mast cells (RBL-2H3). It exhibits immunomodulatory, anti-inflammatory and anti-apoptotic properties. The physiologic mechanisms ...