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Browsing Bioquímica Médica y Biología Molecular e Inmunología by Author "Labrador Garrido, Adahir"
Now showing items 1-6 of 6
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PhD Thesis
Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones
Labrador Garrido, Adahir (2017-05-22)This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. ...
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Patent. Invention
Combinaciones de proteínas agregantes y chaperonas moleculares para el tratamiento de proteinopatías o enfermedades conformacionales
Roodveltd Catellani, Cintia; Labrador Garrido, Adahir; Pozo Pérez, David (Organización Mundial de la Propiedad Intelectual (OMPI), 2015-03-19)Las HSPs (chaperonas o proteínas de choque térmico ('heat-shock proteins' o HSPs)) poseen dos características muy valiosas ...
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Article
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers
Mannini, Benedetta; Vecchi, Giulia; Labrador Garrido, Adahir; Fabre, Bertrand; Pozo Pérez, David; Dobson, Christopher M.; Roodveldt, Cintia (American Chemical Society, 2019)The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory ...
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Article
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants
Roodveldt, Cintia; Labrador Garrido, Adahir; Gonzalez-Rey, Elena; Fernández Montesinos, Rafael; Caro, Marta; Lachaud, Christian; Waudby, Christopher A.; Delgado, Mario; Dobson, Christopher M.; Pozo Pérez, David (Public Library Science, 2010) -
Article
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
Villadiego Luque, Francisco Javier; Labrador Garrido, Adahir; Franco, Jaime M.; Leal Lasarte, Magdalena; Genst, Erwin J. de; Dobson, Christopher M.; Pozo Pérez, David; Toledo Aral, Juan José; Roodveldt, Cintia (Wiley, 2018)Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded ...
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Article
Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation
Roodveldt, Cintia; Labrador Garrido, Adahir; González Rey, Elena; Lachaud, Christian; Guilliams, Tim; Fernández Montesinos, Rafael; Benítez Rondan, Alicia; Robledo, Gema; Hmadcha, Abdelkrim; Delgado, Mario; Dobson, Christopher M.; Pozo, D. (PLOS, 2013)In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, ...