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Artículo
Draft Genome Sequence of Saccharomonospora piscinae KCTC 19743T, an Actinobacterium Containing Secondary Metabolite Biosynthetic Gene Clusters
(American Society for Microbioloby, 2020)
The draft genome sequence of Saccharomonospora piscinae KCTC 19743T, with a size of 4,897,614 bp, was assembled into 11 scaffolds containing 4,561 open reading frames and a G+C content of 71.0 mol%. Polyketide synthase and ...
Artículo
Impact of an antimicrobial stewardship program on the incidence of carbapenem resistant gram-negative bacilli: an interrupted time-series analysis
(MDPI, 2021)
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are a critical public health threat, and carbapenem use contributes to their spread. Antimicrobial stewardship programs (ASPs) have proven successful in reducing antimicrobial ...
Artículo
Surprise-induced enhancements in the associability of Pavlovian cues facilitate learning across behavior systems
(American Psychological Association, 2022)
Surprising violations of outcome expectancies have long been known to enhance the associability of Pavlovian cues; that is, the rate at which the cue enters into further associations. The adaptive value of such enhancements ...
Artículo
Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival. Herein, we investigated the cell death mechanism activated in ...
Artículo
Public Stigma toward Women Victims of Intimate Partner Violence: A Systematic Review
(ELSEVIER, 2023)
Public stigma toward women victims of intimate partner violence (IPV) undermines their recovery. However, research on this topic is still recent. This systematic review aimed to analyze the way this stigma was studied, ...
Artículo
Public Stigmatization of Women Victims of Intimate Partner Violence by Professionals Working in the Judicial System and Law Enforcement Agencies in Spain
(SAGE, 2023)
Recent international literature has demonstrated that the public stigma suffered by women victims of intimate partner violence (IPV) makes them less likely to disclose the abuse and to seek help and has a negative influence ...
Artículo
Risk Assessment and Environmental Consequences of the Use of the Allium-derived Compound Propyl-propane Thiosulfonate (PTSO) in Agrifood Applications
(Elsevier, 2023)
The organosulfur compound propyl-propane thiosulfonate (PTSO), mainly found in Allium cepa, has a promising use in the agrifood industry. To confirm its safety for livestock, consumers, and environment, toxicological ...
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved
(Royal Society of Chemistry, 2023-07-20)
The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ((R)-8-OITC), present in watercress, based on the “DAG methodology” as well as to evaluate its ...
Artículo
Hydroxytyrosol and Dopamine Metabolites: Anti-aggregative Effect and Neuroprotective Activity Against α-synuclein-induced Toxicity
(Elsevier, 2023)
The abnormal aggregation of the α-synuclein (αsyn) protein is involved in the formation of Lewy bodies in the brain of patients suffering from Parkinson disease (PD). Hydroxytyrosol (HT), a polyphenolic compound present ...