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Artículo
Glycodendritic structures: Tools to interact with DC-SIGN
(Universidade de São Paulo, 2013)
The key role of carbohydrates in many biological events has attracted the interest of the scientific community. This fact has demanded the access to new tools necessary to understand this role and the interaction of ...
Artículo
Identification of a promising multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus
(Elsevier, 2014)
DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells) which has an important role in some viral infection, notably by HIV and Dengue virus (DV). Multivalent presentation of carbohydrates on ...
Artículo
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
(National Academy of Sciences, 2017)
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer. Although ...
Artículo
A betaine adduct of N-heterocyclic carbene and carbodiimide, an efficient ligand to produce ultra-small ruthenium nanoparticles
(Royal Society of Chemistry, 2015)
The betaine adduct of N-heterocyclic carbene and carbodiimide (ICy·(p-tol)NCN) was found to be a very efficient ligand to prepare very small (1–1.3 nm) ruthenium nanoparticles (RuNPs). The coordination of the ligand on the ...
Artículo
Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles
(Royal Society of Chemistry, 2015)
Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles displaying activity against biofilms. In this work, trimeric thiomannoside clusters conjugated to ...
Artículo
Mechanism of Dihydrogen Splitting by An Apparent Bimetallic Frustrated Lewis Pair based on Ir(III)/Pt(0)
(Wiley-Blackwell, 2023)
The incorporation of transition metals into frustrated Lewis pairs (FLPs) offers multiple opportunities for bond activation and catalysis. In this work, we explore the combination of the Lewis acidic Ir(III) cation ...
Artículo
Electrocatalytic CO2 Reduction with a Binuclear Bis-Terpyridine Pyrazole-Bridged Cobalt Complex
(Wiley-VCH GmbH, 2023)
A pyrazole-based ligand substituted with terpyridine groups at the 3 and 5 positions has been synthesized to form the dinuclear cobalt complex 1, that electrocatalytically reduces carbon dioxide (CO2) to carbon monoxide ...
Artículo
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
(Elsevier, 2024-03-26)
The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, ...
Artículo
A splice-altering homozygous variant in COX18 causes severe sensory-motor neuropathy with oculofacial apraxia
(Elsevier B.V., 2024-10)
Cytochrome-c oxidase (COX) is part of the mitochondrial complex IV (CIV). COX deficiency is usually associated with tRNA variants, and less frequently with variants in COX assembly factors. Mutations in COX subunits encoded ...