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Listar Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja) por autor "García Fernández, José Manuel"
Mostrando ítems 1-20 de 41
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Artículo
A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin
Mazzaglia, Antonio; Micali, Norberto; Villari, Valentina; Zagami, Roberto; Pennisi, R.M.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Sciortino, M.T.; Scolaro, L.M. (John Wiley & Sons, 2017)The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological ...
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Artículo
Antileishmanial activity of sp2-iminosugar derivatives
Sánchez Fernández, Elena Matilde; Gómez Pérez, Veronica; García Hernández, Raquel; García Fernández, José Manuel; Plata, Gabriela B.; Padrón, José M.; Ortiz Mellet, Carmen; Catanys, Santiago; Gamarro, Francisco (Royal Society of Chemistry, 2015)A series of sp2-iminosugar-type glycomimetics bearing S-linked pseudoglycoside substituents (sulfide, sulfoxide and sulfone ...
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Artículo
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
Martínez-Negro, M.; Caracciolo, G.; Palchetti, S.; Pozzi, D.; Capriotti, A.L.; Cavaliere, C.; Laganà, A; Ortiz Mellet, Carmen; Benito, Juan M.; García Fernández, José Manuel; Aicart, Emilio (Elsevier, 2017)The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic ...
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Artículo
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015)The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
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Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts
Navo, C.D.; Corzana, F.; Sánchez Fernández, Elena Matilde; Busto, J.H.; Avenoza, A.; Namba, E.; Higaki, Katsumi; Ortiz Mellet, Carmen; García Fernández, José Manuel; Peregrina, J.M. (Royal Society of Chemistry, 2016)A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been ...
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Conformationally-locked N -glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease
Castilla, Javier; Rísquez Cuadro, Rocio; Higaki, Katsumi; Nanba, Eiji; Ohno, Kousaku; Diaz, Yolanda; Ortiz Mellet, Carmen; García Fernández, José Manuel; Castillón, Sergio (Elsevier, 2015)Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose–2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit ...
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Artículo
Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities
Pflueger, Iris; Charrat, Coralie; Ortiz Mellet, Carmen; García Fernández, José Manuel; Di Giorgio, Christophe; Benito, Juan M. (Royal Society of Chemistry, 2016)Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined ...
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Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions
Martínez, Álvaro; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ...
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Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
Brumshtein, Boris; Aguilar Moncayo, Matilde; Benito, Juan Manuel; García Fernández, José Manuel; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H.; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2011)Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...
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Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry
Przybylsk, Cédric; Benito, Juan M.; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ...
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Artículo
Differential effects of carbohydrates on arabidopsis pollen germination
Hirsche, Jörg; García Fernández, José Manuel; Stabentheiner, Edith; Großkinsky, Dominik K.; Roitsch, Thomas Georg (Oxford University Press, 2017)Pollen germination as a crucial process in plant development strongly depends on the accessibility of carbon as energy ...
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Artículo
Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells
Gallego-Yerga, Laura; Posadas, Inmaculada; Torre, Cristina de la; Ruiz-Almansa, Jesús; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel; Ceña, Valentín (Frontiers Media, 2017)Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ...
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Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan Manuel; Jiménez Blanco, José Luis; Santana Armas, María Luisa; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2022)A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
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Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017)Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Artículo
Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers
Gallego Yerga, Laura; Lomazzi, Michela; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel (Royal Society of Chemistry, 2014)Stable core–shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a ...
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery
Méndez Ardoy, Alejandro; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; García Fernández, José Manuel (Royal Society of Chemistry, 2015)Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling ...
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Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
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Artículo
Mechanocatalytic Depolymerization of Cellulose With Perfluorinated Sulfonic Acid Ionomers
Karam, Ayma; Amaniampong, Prince Nana; García Fernández, José Manuel; Oldani, C.; Marinkovic, S.; Estrine, B.; Vigier, K.O.; Jérôme, F. (Frontiers Media, 2018)Here, we investigated that the mechanocatalytic depolymerization of cellulose in the presence of Aquivion, a sulfonated ...