Buscar
Mostrando ítems 1-10 de 64
Artículo
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial ...
Artículo
Dialkylterphenyl Phosphine-Based Palladium Precatalysts for Efficient Aryl Amination of N-Nucleophiles
(Wiley-Blackwell, 2020)
A series of 2-aminobiphenyl palladacycles supported by dialkylterphenyl phosphines, PR2Ar′ (R=Me, Et, iPr, Cyp (cyclopentyl), Ar′=ArDipp2, ArXyl2f, Dipp (2,6-C6H3-(2,6-C6H3-(CHMe2)2)2), Xyl=xylyl) have been prepared and ...
Artículo
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its ...
Artículo
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
(MDPI, 2022)
Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary tracts, and the gall bladder. Within the liver, hepatocellular carcinoma (HCC) is the most common type ...
Artículo
Structural diversity and magnetic properties of copper(ii) quinaldinate compounds with amino alcohols
(Royal Society of Chemistry, 2022)
The reactions between [Cu(quin)2(H2O)] (quin− = the anionic form of quinoline-2-carboxylic acid) and a series of aliphatic amino alcohols have yielded structurally very diverse copper(II) complexes, labelled a–g. Single-crystal ...
Artículo
ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
(Springer, 2021)
Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation ...
Artículo
Thinking up an original scientific research project
(Turk Biyokimya Dernegi, 2022)
Writing a research proposal is not a simple task if we wish-and we do usually wish!-to succeed in putting our project into practice. Three different developing stages should indeed be clearly borne in mind from the very ...
Artículo
Enhanced Stability of Perovskite Solar Cells Incorporating Dopant-Free Crystalline Spiro-OMeTAD Layers by Vacuum Sublimation
(Wiley-Blackwell, 2020)
The main handicap still hindering the eventual exploitation of organometal halide perovskite-based solar cells is their poor stability under prolonged illumination, ambient conditions, and increased temperatures. This ...
Artículo
Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues
(Royal Society of Chemistry, 2021)
The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because these compounds pave the way for modulation of the biological ...
Artículo
Membraneless organelles: a smart design for metabolic control
(Wiley Online Library, 2021)
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in the cell by avoiding the mixture of their components with the surroundings. Actually, liquid–liquid ...