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Artículo
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial ...
Artículo
Direct evidence for a coordination-insertion mechanism of ethylene oligomerization catalysed by neutral 2,6-bisiminopyridine iron monoalkyl complexes
(Royal Society of Chemistry, 2014)
1H NMR studies on ethylene oligomerization catalysed by the neutral monoalkyl complex [Fe(Me)(iPrBIP)] allow direct observation of alkyl iron intermediates as well as reversible ethylene coordination to the metal center, ...
Artículo
Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle
(Springer Nature, 2023)
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial ...
Artículo
Characterization of the kisspeptin system in human sperm
(European Academy of Andrology, 2012)
Kisspeptin, the product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. However, the presence of kisspeptin and its ...
Artículo
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its ...
Artículo
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
(MDPI, 2022)
Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary tracts, and the gall bladder. Within the liver, hepatocellular carcinoma (HCC) is the most common type ...
Artículo
β-Hydrogen Elimination Reactions of Nickel and Palladium Methoxides Stabilised by PCP Pincer Ligands
(John Wiley & Sons, 2015)
Nickel and palladium methoxides [((iPr)PCP)M-OMe], which contain the (iPr)PCP pincer ligand, decompose upon heating to give products of different kinds. The palladium derivative cleanly gives the dimeric Pd(0) complex ...
Artículo
Preparation of Chitosan-supported Urea Materials and their Application in Some Organocatalytic Procedures
(Elsevier, 2018)
An efficient and mild procedure was developed for the preparation of three chitosan-supported ureas containing electron-withdrawing groups. These catalysts were characterized and employed as organocatalysts in different ...
Artículo
Pharmacological chaperone therapy for Gaucher disease: A patent review
(Taylor & Francis, 2011)
Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant protein misfolding effects and result in progressive ...
Artículo
ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
(Springer, 2021)
Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation ...