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Artículo
Ginsenosides act as positive modulators of P2X4 receptors
(American Society for Pharmacology and Experimental Therapeutics (ASPET), 2019)
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human ...
Artículo
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
(Nature Research (part of Springer Nature): Fully open access journals, 2019)
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. enhancement of P2X7 receptor responses may ...
Artículo
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
(Royal Society of Chemistry: Open Access, 2019)
The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the first clinical agent has now been approved, but PPIs remain difficult targets for the development of ...
Artículo
Correction: Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
(Royal Society of Chemistry: Open Access, 2019)