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Artículo
Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
(Elsevier, 2023)
Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore NAMPT represents an interesting target for the development of anti-cancer drugs. Several compounds, ...
Artículo
Visible and NIR Light Assistance of the N2 Reduction to NH3 Catalyzed by Cs-promoted Ru Nanoparticles Supported on Strontium Titanate
(American Chemical Society, 2022)
NH3 production accounts for more than 1% of the total CO2 emissions and is considered one of the most energy-intensive industrial processes currently (T > 400 °C and P > 80 bars). The development of atmospheric-pressure ...
Artículo
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein ...