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Mostrando ítems 431-440 de 466
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sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)
The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a glycomimetic moiety and a photoactive azobenzene module, results in conjugates with differences in ...
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A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
(MDPI, 2023-11-25)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which ...
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Fucosidases from the human gut symbiont Ruminococcus gnavus
(Springer, 2021)
The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation of gut bacteria species to ecological niches. To access this source of nutrients, gut bacteria encode ...
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Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction
(Amer chemical SOC, 2023-08-30)
A highly enantio- and diastereoselective dynamic kinetic resolution (DKR) of configurationally labile 3-aryl indole-2-carbaldehydes is described. The DKR proceeds via a Rh-catalyzed intermolecular asymmetric reductive aldol ...
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Excited-state dynamics in borylated arylisoquinoline complexes in solution and in cellulo
(Wiley-V C H Verlag GMBH, 2022-12-07)
Two four-coordinate organoboron N,C-chelate complexes with different functional terminals on the PEG chains are studied with respect to their photophysical properties within human MCF-7 cells. Their excited-state properties ...
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La implicación del alumnado como fuerza motriz en el desarrollo de la asignatura Experimentación en Química II
(Universidad de Sevilla, 2023)
El ciclo de mejora aplicado en la asignatura Experimentación en Química II del Grado en Ingeniería Química Industrial corresponde a una continuación del modelo de actuación en el aula de ciclos de mejora previos realizados ...
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Multivalent glycosystems for human lectins
(Royal Society of Chemistry, 2022-08-30)
Human lectins are involved in a wide variety of biological processes, both physiological and pathological, which have attracted the interest of the scientific community working in the glycoscience field. Multivalent ...
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Green Oxidative Catalytic Processes for the Preparation of APIs and Precursors
(MDPI, 2023-03-22)
Asymmetric oxidation processes have constituted a valuable tool for the synthesis of active pharmaceutical ingredients (APIs), especially for the preparation of optically active sulfoxides, compounds with interesting ...
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N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease
(Elsevier, 2023-07-08)
The oxindole core is an important structural motif in many natural and synthetic substances with various biological activities including anticancer, antineurodegenerative, and antimicrobial properties. This report focuses on ...