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Artículo
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Pd-Catalyzed Dynamic Kinetic Asymmetric Cross-Coupling of Heterobiaryl Bromides with N-Tosylhydrazones
(American Chemical Society, 2022)
A dynamic kinetic asymmetric Pd-catalyzed cross-coupling reaction of heterobiaryl bromides with ketone N-tosylhydrazones for the synthesis of heterobiaryl styrenes is described. The combination of Pd(dba)2 as a precatalyst ...
Artículo
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Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
(Elsevier, 2024-02-13)
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for the design of selective antiproliferative agents. We have accomplished the conjugation of a coumarin ...
Artículo
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Atroposelective Synthesis of 2-(Quinolin-8-yl)benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
(Wiley, 2023-12-22)
A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of 2-(quinoline-8-yl) 3-methylbenzaldehydes and 1-naphthaldehydes is described. The reaction proceeds by atroposelective carbonyl reduction catalyzed ...
Tesis Doctoral
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Nuevos ligandos fosforados voluminosos y sus complejos mono- y dinucleares de platino: síntesis, propiedades y estudios computacionales
(2023-06-16)
Esta tesis doctoral tiene como hilo conductor los ligandos fosforados consustituyentes voluminosos, tratando de la síntesis de varias familias de estos ligandos, desus complejos (principalmente de platino) y de la reactividad ...
Artículo
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High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin
(Wiley, 2023-10-12)
The “carbohydrate chemical mimicry” exhibited by sp2-iminosugars has been utilized to develop practical syntheses for analogs of the branched high-mannose-type oligosaccharides (HMOs) Man3 and Man5. In these compounds, the ...
Tesis Doctoral
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Caracterización química de ligninas y lípidos de cultivos y residuos agrícolas
(2024-04-05)
La presente Tesis Doctoral aborda la caracterización química de las ligninas y los lípidos presentes en diversos materiales lignocelulósicos, incluyendo tanto residuos derivados de la actividad agrícola (cascarilla y ...
Artículo
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Divergent approach to nanoscale glycomicelles and photo-responsive supramolecular glycogels. Implications for drug delivery and photoswitching lectin affinity
(Royal Society of Chemistry, 2023-10-09)
The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications in diverse areas such as cancer theranostics, tissue engineering, and catalysis. However, designing ...
Tesis Doctoral
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Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos
(2020-05-24)
En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre sistemas [2.2.1]bicíclicos (7-heteronorbornanos y 7- heteronorbornadienos), así como su aplicación ...
Artículo
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Mechanically Planar-to-Point Chirality Transmission in [2]Rotaxanes
(American Chemical Society, 2024-01-24)
Herein we describe an effective transmission of chirality, from mechanically planar chirality to point chirality, in hydrogen-bonded [2]rotaxanes. A highly selective mono-N-methylation of one (out of four) amide N atom at ...
Artículo
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Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
(American Chemical Society, 2024-01-02)
STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small molecules and low molecular weight fragments with a given macromolecule, identifying the main intermolecular ...