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Tesis Doctoral
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1-Alquil-2-benciltio-4-imidazolcarbozaldehidos
(1967-10-31)
Artículo
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Pharmacological Chaperones for the Treatment of α-Mannosidosis
(American Chemical Society, 2019)
α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation in the lysosome, leading to severe pathology. Many of the AM-causative mutations compromise enzyme ...
Artículo
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Organocatalysis and Biocatalysis Hand in Hand: Combining Catalysts in One-Pot Procedures
(Wiley, 2017)
Multi-step processes catalysed by several catalysts working concurrently have been developed in nature, thus improving reaction efficiency. The quest for novel and improved catalytic systems has led to the development of ...
Artículo
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Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
(Royal Society of Chemistry: Open Access, 2015)
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of a-D-mannose or b-Dglucose to modulate the ...
Artículo
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Nanoparticle-delivered HIV peptides to dendritic cells a promising approach to generate a therapeutic vaccine
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Finding a functional cure for HIV-1 infection will markedly decrease the social and economic burden of this disease. In this work, we have taken advantage of the antigen presenting cell role of human dendritic cells (DCs) ...
Artículo
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts in the [3 + 2] cycloaddition reaction between alkyl allenoates and electron-deficient imines. The ...
Artículo
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Continuous flow synthesis of PCN-222 (MOF-545) with controlled size and morphology: a sustainable approach for efficient production
(Royal Society of Chemistry, 2023-11-21)
Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, versatile structure and exceptional thermal/chemical stability. However, the synthesis of PCN-222 ...
Tesis Doctoral
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Sistemas de transporte molecular basados en ciclooligosacáridos y dendrímeros
(2021-01-29)
La terapia génica es una modalidad de medicina molecular que consiste en transferir al interior celular material génico capaz de interferir en la biosíntesis de proteínas implicadas, bien por su ausencia o por su presencia, ...
Artículo
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sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
(Elsevier, 2019)
Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic tail, termed sp2-iminosugar glycolipids (sp2-IGLs), target microglia during neuroinflammatory ...
Artículo
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Dynamic kinetic resolution of 2-(Quinolin-8-yl)benzaldehydes: atroposelective iridium-catalyzed transfer hydrogenative allylation
(Wiley-V C H Verlag GMBH, 2023-06-30)
An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8- yl)benzaldehydes/1-naphthaldehydes by transfer hydrogenative coupling of allyl acetate is disclosed. The allylation reaction takes place ...