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Mostrando ítems 251-260 de 466
Artículo
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
(Nature Publishing Group, 2015)
Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal β-glucocerebrosidase. Homozygosity for the L444P mutation in GBA1 is associated with high risk of neurological manifestations which are ...
Artículo
Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors
(MDPI, 2024-02-02)
Deep Eutectic Solvents (DESs) have appeared in recent years as an appealing alternative to classical organic solvents, due to their valuable environmental properties. In addition, these compounds, formed by the combination ...
Tesis Doctoral
Tesis Doctoral
Aislamiento y caracterización de formas de materia orgánica refractaria en sedimentos marinos. Implicaciones ambientales
(2007-06-22)
Debido a la amenaza del calentamiento global se ha despertado un enorme interés por el estudio de los factores y mecanismos que determinan la acumulación de formas estables de Carbono y los procesos para mitigar las emisiones ...
Artículo
Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019)
(MDPI, 2019-09-25)
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This ...
Artículo
Bacterial enzymes involved in lignin degradation
(Elsevier, 2016)
Lignin forms a large part of plant biomass. It is a highly heterogeneous polymer of 4-hydroxyphenylpropanoid units and is embedded within polysaccharide polymers forming lignocellulose. Lignin provides strength and rigidity ...
Artículo
Gene Replacement and Fluorescent Labeling to Study the Functional Role of Exopolysaccharides in Bifidobacterium animalis subsp. lactis
(Frontiers Media, 2017)
An extracellular layer of exopolysaccharides (EPS) covers the surface of some Bifidobacterium animalis subsp. lactis strains, which could be of relevance for its probiotic performance. In order to understand the functional ...
Tesis Doctoral
Estructura tridimensional de inositol fosfoglicanos mediante rmn, mecánica y dinámica molecular
(2016-02-09)
En enero de 1997 se firmó un convenio entre la empresa británica Hoëft-Rademacher Limited, que más tarde pasó a llamarse Rademacher Group Limited y luego Rodaris Pharmaceuticals, y el Consejo Superior de Investigaciones ...
Artículo
Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors
(2004)
Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a variety of nitriles results in the formation of fused or spiro 2-oxazolines. The reaction implies (i) ...
Artículo
A novel approach to the synthesis of N-substituted 1-C-aminomethyl glycofuranosides
(2006)
Reductive amination of formyl C-glycofuranosides, easily available from hexose-derived equatorial-2-OH-glycopyranosides by DAST-promoted ring contraction, afforded N-substituted 1-C-aminomethyl glycofuranosides in most ...