Listar Química Orgánica por agencia financiadora "Universidad de Sevilla"
Mostrando ítems 1-15 de 15
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Artículo
Asymmetric Dearomatization of Phthalazines by Anion-BindingCatalysis
(American Chemical Society, 2023-12-01)A straightforward methodology for the enantioselective synthesis of 1,2-dihydrophthalazines via dearomatization of ...
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Biocompatible metal-organic frameworks as promising platforms to eradicate HIV reservoirs ex vivo in people living with HIV
(Royal Society of Chemistry, 2024-04-17)The HIV attacks the immune system provoking an infection that is considered a global health challenge. Despite antiretroviral ...
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Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
(Elsevier, 2016)Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
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Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation
(MDPI, 2020-12)Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
(Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
(Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
(Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes
(Elsevier, 2020)Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest ...
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Non-Ionic Osmotic Stress Induces the Biosynthesis of Nodulation Factors and Affects Other Symbiotic Traits in Sinorhizobium fredii HH103
(MDPI, 2023)Simple Summary: Rhizobia are soil proteobacteria able to establish nitrogen-fixing symbiosis with host legumes. This ...
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Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives
(American Chemical Society, 2023)β-cyclodextrin (βCyD) derivatives equipped with aromatic appendages at the secondary face exhibit tailorable self-assembling ...
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Solvent-free synthesis of quaternary alpha-hydroxy alpha-trifluoromethyl diazenes: the key step of a nucleophilic formylation strategy
(Royal Society of Chemistry, 2016)An efficient, scalable and operationally simple one-pot, 2-step strategy for the nucleophilic formylation of trifluoromethyl ...
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sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a ...
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
(Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
(American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
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Tackling Antibiotic Resistance: Influence of Aliphatic Branches on Broad-Spectrum Antibacterial Polytriazoles against ESKAPE Group Pathogens
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)One of the most important threats to public health is the appearance of multidrug-resistant pathogenic bacteria, since ...