Listar Química Orgánica por agencia financiadora "Ministerio de Economía y Competitividad (MINECO). España"
Mostrando ítems 1-20 de 45
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Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
(Wiley-Blackwell, 2019)The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the ...
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AuI-Catalyzed Haloalkynylation of Alkenes
(Wiley-Blackwell, 2020)The formal insertion of alkenes into aromatic chloro- and bromoalkynes takes place under cationic gold catalysis. This ...
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Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes
(American Chemical Society, 2012)The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction ...
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Bifunctional Squaramide Organocatalysts for the Asymmetric Addition of Formaldehyde tert-Butylhydrazone to Simple Aldehydes
(Wiley-Blackwell, 2018)The nucleophilic addition of formaldehyde tert-butylhydrazone to simple aldehydes (a formal hetero-carbonyl–ene reaction) ...
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Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose
(American Chemical Society, 2017)Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ...
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Chemoenzymatic synthesis and radical scavenging of sulfated hydroxytyrosol, tyrosol, and acetylated derivatives
(American Chemical Society, 2019-07-03)Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for ...
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Chirality and catalysis with aromatic N-fused heterobicyclic carbenes
(Royal Society of Chemistry, 2016)The benzoannulation of the most common families of aromatic NHCs, imidazol-2-ylidenes and 1,2,4-triazol-3-ylidenes, results ...
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Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study
(Royal Society of Chemistry, 2015)Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples ...
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Cyclopentyl Methyl Ether (CPME): A Versatile Eco-Friendly Solvent for Applications in Biotechnology and Biorefineries
(Wiley, 2019-05)The quest for sustainable solvents is currently a matter of intense research and development, as solvents significantly ...
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Deracemisation Processes Employing Organocatalysis and Enzyme Catalysis
(Wiley-Blackwell, 2020)Deracemisation methods have demonstrated their importance in the preparation of chiral compounds in the last few years. ...
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Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018)The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
(Elsevier, 2022)Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules
(Royal Society of Chemistry, 2016)A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized ...
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Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
(Elsevier, 2016)Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
(Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Gene Replacement and Fluorescent Labeling to Study the Functional Role of Exopolysaccharides in Bifidobacterium animalis subsp. lactis
(Frontiers Media, 2017)An extracellular layer of exopolysaccharides (EPS) covers the surface of some Bifidobacterium animalis subsp. lactis ...
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
(Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ...
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Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products
(Elsevier, 2015-11-15)The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product ...
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Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017)Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...