dc.creator | Molina-Solana, Pedro | es |
dc.creator | Domínguez-Serrano, Antonio Manuel | es |
dc.creator | Garrido-Hermosilla, Antonio M. | es |
dc.creator | Montero Iruzubieta, Jesús | es |
dc.creator | Fernández Palacín, Ana | es |
dc.creator | Rodríguez de la Rúa Franch, Enrique | es |
dc.creator | Caro Magdaleno, Manuel | es |
dc.date.accessioned | 2021-05-20T11:08:21Z | |
dc.date.available | 2021-05-20T11:08:21Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Molina-Solana, P., Domínguez-Serrano, A.M., Garrido-Hermosilla, , Montero Iruzubieta, J., Fernández Palacín, A., Rodríguez de la Rúa Franch, E. y Caro Magdaleno, M. (2021). Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use. Clinical Ophthalmology, 14, 1153-1559. | |
dc.identifier.issn | 1177-5467 | es |
dc.identifier.uri | https://hdl.handle.net/11441/109108 | |
dc.description.abstract | Purpose: Artificial tears only provide transient relief for dry eye. To the best of our
knowledge, this is the first study to objectively compare treatment with artificial tears with
Keratograph 5M, which allows accurate and objective investigation of dry eye and artificial
tear treatment. We aimed to evaluate whether a preservative-free combination of 0.4%
hyaluronic acid and 0.2% galactoxyloglucan can improve dry eye using the new topographer,
Keratograph 5M.
Patients and Methods: This prospective longitudinal, single-arm interventional cohort
study was performed at a tertiary referral center and involved 20 patients with dry eye (40
eyes). Preservative-free artificial tears were administered every 3 h. The participants under went clinical and instrumental evaluations at baseline, 15, 30, 60, 90 and 120 min after
instillation and 1 week and 1 month after treatment. Baseline values were considered as the
controls. All patients were assessed with Keratograph 5M for non-invasive Keratograph first
break-up time and non-invasive Keratograph average break-up time, conjunctival hyperemia,
and tear meniscus height. Ocular surface staining with fluorescein was evaluated using the
slit-lamp and fluorescein break-up time examinations, and the Ocular Surface Disease Index
score was recorded for each patient.
Results: The signs and symptoms improved after 1 month of preservative-free 0.4%
hyaluronic acid and 0.2% galactoxyloglucan treatment. There was a significant increase in
the non-invasive Keratograph first break-up time and non-invasive Keratograph average
break-up time at 15, 30, 60, and 90 min, and 1 week and 1 month (P < 0.05) and
a decrease in hyperemia, corneal staining, and Ocular Surface Disease Index scores after 1
week and 1 month (P < 0.05). No treatment-related adverse event was observed.
Conclusion: A combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan artificial
tears seems effective for treating dry eye. Keratograph 5M can objectively detect these
changes during the follow-up period. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Clinical Ophthalmology, 14, 1153-1559. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Artificial tears | es |
dc.subject | Keratograph | es |
dc.subject | Non-invasive Keratograph break-up time | es |
dc.subject | Ocular Surface Disease Index | es |
dc.subject | Dry eye | es |
dc.title | Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.journaltitle | Clinical Ophthalmology | es |
dc.publication.volumen | 14 | es |
dc.publication.initialPage | 1153 | es |
dc.publication.endPage | 1559 | es |