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Artículo
Securin Is a Target of the UV Response Pathway in Mammalian Cells
(2004)
All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to ...
Artículo
Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
(Springer Nature, 2023)
Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment of different types of cancer. However, it is common to find patients who respond well to treatment at ...
Artículo
p53 and FBXW7: Sometimes Two Guardians Are Worse than One
(MDPI, 2020)
Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of ...
Artículo
Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
(The American Society for Biochemistry and Molecular Biology, 2011)
PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during mitosis. At the metaphase-to-anaphase transition, securin is targeted for proteasomal destruction ...