Now showing items 1-3 of 3
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase [Article]
Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. For most of the cell cycle, separase activity is kept in check by its association with the ...
Heterologous viral expression systems in fosmid vectors increase the functional analysis potential of metagenomic libraries [Article]
(Nature Publishing Group, 2013)
The extraordinary potential of metagenomic functional analyses to identify activities of interest present in uncultured microorganisms has been limited by reduced gene expression in surrogate hosts. We have developed vectors ...
UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase [Article]
(Company of Biologists, 2008)
Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid separation until the onset of anaphase, and it also takes part in cell-cycle arrest after UV irradiation. ...