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Artículo
In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria
(American Society for Microbiology, 1998-12-01)
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against ...
Artículo
Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes
(American Society for Microbiology, 1993-01-01)
The penetration of fluconazole into human polymorphonuclear leukocytes (PMNs) and tissue culture epithelial cells (McCoy) was evaluated. At different extracellular concentrations (0.5 to 10 mg/liter), fluconazole reached ...
Artículo
Comparison of broth microdilution and E-test for susceptibility testing of Neisseria meningitidis
(American Society for Microbiology, 1996)
The susceptibilities of 54 clinical isolates of Neisseria meningitidis to penicillin, cefotaxime, ceftriaxone, cefepime, imipenem, ciprofloxacin, chloramphenicol, and rifampin were determined by the microdilution method ...
Artículo
Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae
(American Society for Microbiology, 1999-07-01)
Two clinical isolates of extended-spectrum β-lactamase (ESBL)- producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels ...
Artículo
Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells
(American Society for Microbiology, 1999-02-15)
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At extracellular concentrations of 5 ...
Artículo
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
(American Society for Microbiology, 1999-01-01)
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to ...
Artículo
Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells
(American Society for Microbiology, 1997-02-01)
The penetration of trovafloxacin into human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and tissue-cultured epithelial cells (McCoy cells) was evaluated. The cellular concentration to extracellular ...
Artículo
Antimicrobial susceptibility pattern of Corynebacterium striatum
(American Society for Microbiology, 1996-11-01)
The in vitro activities of 16 antimicrobial agents against 86 strains of Corynebacterium striatum were evaluated by microdilution using cation- adjusted Mueller-Hinton broth. MICs at which 90% of strains were inhibited ...
Artículo
Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
(American Society for Microbiology, 1998-07-01)
The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation ...
Artículo
Uptake and intracellular activity of sparfloxacin in human polymorphonuclear leukocytes and tissue culture cells
(American Society for Microbiology, 1992-01-01)
The penetration of sparfloxacin into human neutrophils (PMN) and different tissue culture cells (HEp-2 and McCoy) was evaluated. The cellular to extracellular concentration ratios (C/E) of sparfloxacin were always higher ...