Now showing items 1-8 of 8

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      Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer  [Article]

      Galindo Moreno, María; Giráldez Macías, Servando; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Nature Publishing Group, 2017)
      Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis. Due to ...
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      Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase  [Article]

      Tortolero García, María Dolores; Romero Portillo, Francisco; Bernal Rodríguez, Juan Antonio; Ramos Morales, Francisco; Domínguez, África (2001)
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      Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer  [Article]

      Gasca, Jessica; Flores de Mera, María de la Luz; Giraldez Macias, Servando; Tortolero García, María Dolores (Impact Journals, 2016)
      FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins for ubiquitination and degradation by the proteasome. FBXW7 regulates cellular apoptosis by ...
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      Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells  [Article]

      Jiménez Guerrero, Rocío; Gasca Bellido, Jessica María; Flores, M. Luz; Pérez Valderrama, Begoña; Medina, Rafael; Tortolero García, María Dolores; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (MDPI, 2018)
      Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein ...
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      p53 and FBXW7: Sometimes Two Guardians Are Worse than One  [Article]

      Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (MDPI, 2020)
      Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute to tumorigenesis. Here, we reflect on the results of three laboratories describing the role of ...
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      Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase  [Article]

      Gil Bernabé, Ana María; Romero Portillo, Francisco; Limón Mortés, María Cristina; Tortolero García, María Dolores (2006)
      Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. For most of the cell cycle, separase activity is kept in check by its association with the ...
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      Securin Is a Target of the UV Response Pathway in Mammalian Cells  [Article]

      Romero Portillo, Francisco; Gil-Bernabé, Ana M.; Sáez, Carmen; Pintor Toro, José Antonio; Tortolero García, María Dolores (2004)
      All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to ...
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      UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase  [Article]

      Limón Mortés, María Cristina; Mora Santos, María del Mar; Espina Zambrano, Águeda Gema; Pintor Toro, José Antonio; López Román, Antonio; Tortolero García, María Dolores; Romero Portillo, Francisco (Company of Biologists, 2008)
      Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid separation until the onset of anaphase, and it also takes part in cell-cycle arrest after UV irradiation. ...