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Listar Artículos (Microbiología) por autor "Tortolero García, María Dolores"
Mostrando ítems 1-13 de 13
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Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer
Galindo Moreno, María; Giráldez Macías, Servando; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Nature Publishing Group, 2017)Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic ...
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Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
Belmonte Fernández, Alejandro; Herrero Ruiz, Joaquín; Galindo Moreno, María; Limón Mortés, María Cristina; Mora Santos, María del Mar; Sáez, Carmen; Japón, Miguel A.; Tortolero García, María Dolores; Romero Portillo, Francisco (Springer Nature, 2023)Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ...
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EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells
Gasca, Jessica; Flores, María Luz; Jiménez Guerrero, Rocío; Sáez, M. E.; Barragán, Isabel; Ruíz Borrego, Manuel; Tortolero García, María Dolores; Romero Portillo, Francisco; Sáez, Carmen; Japón, Miguel Á. (Springer Nature, 2020)Epithelial–mesenchymal transition (EMT) has recently been associated with tumor progression, metastasis, and chemotherapy ...
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Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
Mora Santos, María del Mar; Limón Mortés, María Cristina; Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (The American Society for Biochemistry and Molecular Biology, 2011)PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ...
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Grb2 and Its Apoptotic Isoform Grb3-3 Associate with Heterogeneous Nuclear Ribonucleoprotein C, and These Interactions Are Modulated by Poly(U) RNA
Romero Portillo, Francisco; Ramos Morales, Francisco; Domínguez, África; Ríos Sánchez, Rosa María; Schweighoffer, Fabien; Tocqué, Bruno; Pintor Toro, José Antonio; Fischer, Siegmund; Tortolero García, María Dolores (Elsevier, 1998)Grb2 is an adaptor molecule comprising one Src homology (SH) 2 and two SH3 domains. This protein has a natural isoform ...
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Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase
Tortolero García, María Dolores; Romero Portillo, Francisco; Bernal Rodríguez, Juan Antonio; Ramos Morales, Francisco; Domínguez, África (2001) -
Artículo
Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer
Gasca, Jessica; Flores de Mera, María de la Luz; Giraldez Macias, Servando; Tortolero García, María Dolores; Ruiz-Borrego, Manuel; Romero Portillo, Francisco; Japón, Miguel A.; Sáez, Carmen (Impact Journals, 2016)FBXW7 is a component of SCF (complex of SKP1, CUL1 and F-box-protein)-type ubiquitin ligases that targets several oncoproteins ...
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Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
Jiménez Guerrero, Rocío; Gasca Bellido, Jessica María; Flores, M. Luz; Pérez Valderrama, Begoña; Medina López, Rafael; Tortolero García, María Dolores; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (MDPI, 2018)Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and ...
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p53 and FBXW7: Sometimes Two Guardians Are Worse than One
Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (MDPI, 2020)Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute ...
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Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase
Gil Bernabé, Ana María; Romero Portillo, Francisco; Limón Mortés, María Cristina; Tortolero García, María Dolores (2006)Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. ...
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SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability
Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Impact Journals LLC, 2014)The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response ...
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Securin Is a Target of the UV Response Pathway in Mammalian Cells
Romero Portillo, Francisco; Gil-Bernabé, Ana M.; Sáez, Carmen; Pintor Toro, José Antonio; Tortolero García, María Dolores (2004)All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing ...
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UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase
Limón Mortés, María Cristina; Mora Santos, María del Mar; Espina Zambrano, Águeda Gema; Pintor Toro, José Antonio; López Román, Antonio; Tortolero García, María Dolores; Romero Portillo, Francisco (Company of Biologists, 2008)Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid ...