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      Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes  [Article]

      Hernández Allés, Santiago; Benedí, Vicente J.; Martínez Martínez, Luis; Pascual Hernández, Álvaro; Aguilar, Alicia; Tomás, Juan M.; Albertí, Sebastián (American Society for Microbiology, 1999-01-01)
      We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to ...