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Artículo
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Characterization of Extended-Spectrum β-Lactamase-Producing Shigella sonnei in Spain: Expanding the Geographic Distribution of Sequence Type 152/CTX-M-27 Clone
(American Society for Microbiology, 2022-07)
We describe the first occurrence in Spain of community cases of CTX-M-27-producing Shigella sonnei sequence type 152 (ST152), resistant to quinolones and azithromycin. The cases included adult males and also one pediatric ...
Artículo
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Identification of a Stable Chromosomal Tandem Multicopy of bla(VIM-63), a New bla(VIM-2) Carbapenemase
(American Society for Microbiology, 2022-07)
This study characterizes a new genetic structure containing a multicopy of a bla(VIM-2) variant with an A676C substitution, bla(VIM-63). This gene was detected on the chromosome of two carbapenem-resistant clinical strains ...
Artículo
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A lipopolysaccharide-free outer membrane vesicle vaccine protects against Acinetobacter baumannii infection
(Elsevier, 2020-01)
Outer membrane vesicles (OMVs) were isolated from an Acinetobacter strain deficient in lipopolysaccharide (LPS) due to a mutation in lpxD (IB010). Two immunizations with 10 µg of IB010 OMVs elicited total IgG, IgM, IgG1 ...
Tesis Doctoral
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Farmacocinética y farmacodinamia de piperacilina/tazobactam y fosfomicina en pacientes con bacteriemia por enterobacteriaceae
(2024-05-02)
En esta tesis se aborda el estudio de la farmacocinética y farmacodinamia de dos antimicrobianos en bacteriemias por enterobacterias. Por un lado, piperacilina-tazobactam (PTZ), donde se analiza la variabilidad farmacocinética ...
Artículo
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Synergistic effect of SOS response and GATC methylome suppression on antibiotic stress survival in Escherichia coli
(https://journals.asm.org/doi/epdf/10.1128/aac.01392-22, 2023-03)
The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent base methylation has an impact on susceptibility to other antimicrobials affecting DNA synthesis. ...
Artículo
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RecA inactivation as a strategy to reverse the heteroresistance phenomenon in clinical isolates of Escherichia coli
(Elsevier, 2023-02)
RecA inhibition could be an important strategy to combat antimicrobial resistance because of its key role in the SOS response, DNA repair and homologous recombination contributing to bacterial survival. This study evaluated ...
Artículo
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Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia
(Elsevier, 2018-11)
Objective: To evaluate the ability of the BioFire FilmArray Blood Culture Identification (BCID) panel to rapidly detect pathogens producing late-onset ventilator-associated pneumonia (VAP), a severe infection often ...
Artículo
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Immunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection
(Elsevier, 2018-07-05)
Outer membrane complex (OMC) vaccines, which contain antigens from the bacterial outer membrane, have been developed for multiple Gram-negative bacteria. However, OMC vaccines demonstrate high endotoxin activity due to the ...
Artículo
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Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii
(Taylor & Francis, 2018)
Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used ...
Artículo
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First Steps Towards a Vaccine against Acinetobacter baumannii
(Bentham Science, 2013)
Acinetobacter baumannii has become an important cause of human infections, most notably in the hospital setting. In addition, the global dissemination of multidrug resistant strains has complicated effective antibiotic ...