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Tesis Doctoral
Crosstalk between DNA end resection and RNA metabolism
(2020-01-23)
DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to ...
Tesis Doctoral
Unraveling the connection between centrosomes and the DNA damage response
(2023-06-20)
Centrosomes act as the major microtubule (MT) organizing centers (MTOC) in most animal cells. Structural or numerical defects in this organelle are associated with chromosome missegregation, polarity defects and ...
Tesis Doctoral
Regulation of DNA end resection by cell stemness
(2020-01-20)
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic applications, however, acquired genomic instability is one of the major concerns for its clinical use. The ...
Tesis Doctoral
Molecular basis of Aicardi-Goutières syndrome
(2023-09-21)
DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous damage. One of the most dangerous injuries in DNA are doublestrand breaks. There are two main ...
Tesis Doctoral
Non-canonical DNA structures in Double Strand Break repair
(2023-05-22)
DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell viability. To repair them, the cell has evolved two main alternative mechanisms, non-homologous ...