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Tesis Doctoral
Artículo
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A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking transcription elongation with mRNA export and genome stability, as shown for specific reporters. ...
Artículo
Tesis Doctoral
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Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma
(2017-09-13)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos procesos altamente regulados trabajan de forma coordinada para evitar o solucionar problemas que pueden ...
Tesis Doctoral
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Ingeniería genética aplicada a la superproducción de treonina en Saccharomyces cerevisiae
(1997)
El objetivo de esta Tesis ha sido estimar hasta qué punto es posible optimizar la producción de treonina por S. cerevisiae mediante la manipulación in vitro de genes de su ruta de biosíntesis. Se partía del conocimiento ...
Artículo
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CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis
(Rockefeller University Press, 2012)
In mitosis, animal cells lose their adhesion to the surrounding surfaces and become rounded. During mitotic exit, they reestablish these adhesions and at the same time physically contract and divide. How these competing ...
Artículo
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Selection of wine yeasts for growth and fermentation in the presence of ethanol and sucrose
(American Society for Microbiology, 1983)
To optimize the conversion of carbohydrates to ethanol, strains of several Saccharomyces species were examined for the ability to grow and ferment in a range of sucrose and ethanol concentrations. A total of 632 wine yeasts, ...
Artículo
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The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes
(Frontiers Media S.A., 2021)
The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures ...
Artículo
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Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism
(National Academy of Sciences, 2009)
The fungus Phycomyces blakesleeanus reacts to environmental signals, including light, gravity, touch, and the presence of nearby objects, by changing the speed and direction of growth of its fruiting body (sporangiophore). ...
Artículo
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Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells
(1421-9778, 2020)
Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with portal hypertension and/or increased bilirubinemia, but without ...