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Artículo
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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
(Nature Publishing Group, 2021)
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration of RNA, has a profound effect on cell ...
Artículo
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Yeast Sen1 helicase protects the genome from transcription-associated instability
(Elsevier, 2011-01-06)
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses ...
Artículo
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EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
(Nature Research, 2019)
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is ...
Artículo
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Roles of the outer membrane protein asmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells
(American Society for Microbiology, 2009)
A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA ...
Tesis Doctoral
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Variantes mutacionales no seleccionadas de la fosfatasa alcalina de "Escherichia coli"
(1982)
La polémica sobre la importancia relativa de la selección y de la deriva genética en el polimorfismo y la evolución moleculares (neutralismo contra seleccionismo) se encuentra estancada y la solución parece depender del ...
Tesis Doctoral
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Caracterización estructural y funcional de la aspartato quinasa de saccharomyces cerevisiae
(2003-03-03)
Durante la presente tesis se han puesto a punto sendos sistemas de purificaicón de las aspartato quinasa silvestre y la producida como una fusión. El estudio de ambas ha permitido conocer que la estructura cuaternaria ...
Tesis Doctoral
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Adaptation to bile in salmonella enterica
(2013)
Las bacterias pertenecientes al género Salmonella son patógenos Gramnegativos capaces de infectar una gran variedad de animales. En humanos, la infección por Salmonella suele comenzar con la ingestión de agua o alimentos ...
Artículo
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Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF
(Oxford Academic, 2019-09-05)
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon ...
Artículo
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Controlled Transcription of Regulator Gene carS by Tet-on or by a Strong Promoter Confirms Its Role as a Repressor of Carotenoid Biosynthesis in Fusarium fujikuroi
(MDPI, 2020-12)
Carotenoid biosynthesis is a frequent trait in fungi. In the ascomycete Fusarium fujikuroi, the synthesis of the carboxylic xanthophyll neurosporaxanthin (NX) is stimulated by light. However, the mutants of the carS gene, ...
Artículo
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DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
(Frontiers Media, 2019)
DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death or result in genome mutagenesis and chromosomal translocations. Although most of these rearrangements ...