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Intergeneric hybrids of Saccharomyces cerevisiae and Zygosaccharomyces fermentati obtained by protoplast fusion
(American Society for Microbiology, 1986)
To obtain strains that are able to efficiently produce ethanol from different carbohydrates, mainly cellulose hydrolysates, several species of the genus Candida and a Zygosaccharomyces fermentati ...
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Tesis Doctoral
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Non-canonical DNA structures in Double Strand Break repair
(2023-05-22)
DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell viability. To repair them, the cell has evolved two main alternative mechanisms, non-homologous ...
Tesis Doctoral
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Regulación y modificación de rutas biosintéticas de metabolitos con interés industrial en Fusarium fujikuroi
(2024-03-22)
Los hongos filamentosos han sido utilizados como organismos modelos para el estudio de diferentes procesos biológicos como la regulación por la luz y el ritmo circadiano, el control de la esporulación o las interacciones ...
Artículo
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Cell-Type–Specific Transcriptional Profiles of the Dimorphic Pathogen Penicillium marneffei Reflect Distinct Reproductive, Morphological, and Environmental Demands
(Genetics Society of America:, 2013)
Penicillium marneffei is an opportunistic human pathogen endemic to Southeast Asia. At 25° P. marneffei grows in a filamentous hyphal form and can undergo asexual development (conidiation) to produce spores (conidia), the ...
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Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
(Oxford University Press, 2020)
DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer ...
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FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
(Springer Nature, 2022)
Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme hypersensitivity to interstrand crosslink (ICL) agents. Additionally, the FA ...