Buscar
Mostrando ítems 631-640 de 685
Tesis Doctoral
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Una conexión entre el complejo FACT y progresión de la célula Saccharomyces cerevisiae
(2012)
The FACT complex is an essential component of eukaryotic ce ... lls able to modify the chromatin structure allowing transcription by the RNA polymerase II. The FACT that this complex is essential in all organisms tested ...
Tesis Doctoral
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
![Premio Extraordinario de Doctorado US Icon](/themes/idUS/images/certificate.png)
Role of ATM in the repair of blocked DNA double-strand breaks
(2017-02-03)
La Ataxia-telangiectasia (A-T) es un síndrome causado por mutaciones de pérdida de función en la quinasa ATM (Ataxia Telangiectasia mutated). A-T representa el aradigma de los síndromes caracterizados por predisposición a ...
Artículo
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a differential implication of mRNP biogenesis factors in genome integrity in yeast ...
Artículo
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Three Genes Involved in Different Signaling Pathways, carS, wcoA, and acyA, Participate in the Regulation of Fusarin Biosynthesis in Fusarium fujikuroi
(MDPI, 2024)
The phytopathogenic fungus Fusarium fujikuroi has a rich secondary metabolism which includes the synthesis of very different metabolites in response to diverse environmental cues, such as light or nitrogen. Here, we focused ...
Artículo
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Rat1 promotes premature transcription termination at R-loops
(Oxford University Press, 2024-04-24)
Certain DNA sequences can adopt a non-B form in the genome that interfere with DNA-templated processes, including transcription. Among the sequences that are intrinsically difficult to transcribe are those that tend to ...
Tesis Doctoral
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines
(2023-06-07)
El carcinoma hepatocellular (CHC) es reconocido como el principal cáncer primario de hígado y uno de los cánceres con mayor incidencia y mortalidad a nivel mundial. Éste se desarrolla en un contexto de enfermedad hepática ...
Tesis Doctoral
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Role of regulatory proteins in carotenoid biosynthesis and metabolism in Fusarium fujikuroi
(2024-04-12)
La capacidad de los hongos filamentosos de adaptarse a cambios ambientales a cambios ambientales ha conducido al desarrollo de mecanismos sofisticados, como la producción de metabolitos secundarios que, a pesar de no ser ...
Artículo
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)
RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is specifically found in higher eukaryotes and associates with the elongating RNA polymerase II. To ...
Tesis Doctoral
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
New cellular elements associated with DNA:RNA hybrid homeostasis in eukaryotes
(2019-07-12)
El mantenimiento de la integridad del genoma es esencial para el correcto funcionamiento de las funciones celulares así como la transmisión de la información genética a través de las generaciones. La inestabilidad genética ...
Artículo
![Con acceso al texto completo Icon](/themes/idUS//images/acceso/opened_access.png)
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer ...