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Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
(Public Library of Science, 2016)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed impairs mRNA export and cell growth. To investigate further the relevance of proper Yra1 ...
Tesis Doctoral
Artículo
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Purine homeostasis is necessary for developmental timing, germline maintenance and muscle integrity in caenorhabditis elegans
(Genetics Society of America, 2019)
Purine homeostasis is ensured through a metabolic network widely conserved from prokaryotes to humans. Purines can either be synthesized de novo, reused, or produced by interconversion of extant metabolites using the ...
Artículo
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DsbA and MgrB regulate steA expression through the two-component system PhoQ/PhoP in Salmonella enterica.
(American Society for Microbiology, 2013)
SteA is a protein that can be translocated into host cells through the two virulence-related type III secretion systems that are present in Salmonella enterica. We used the T-POP system to carry out general screens for ...
Tesis Doctoral
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Caracterización del gen de la quitinasa CHIT42 del hongo antagonista Trichoderma harzianum y análisis de su expresión en plantas de tabaco
(1997-04-11)
Las especies del género Trichoderma han sido objeto de intensos estudios, dadas sus numerosas aplicaciones prácticas. Su descubrimiento tuvo lugar durante la guerra de Corea, en el sudeste asiático, como consecuencia de ...
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. ...
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Artículo
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Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates
(Bio-Protocol, 2018)
Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein's native conformation, which ultimately results ...
Artículo
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The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development
(Public Library of Science, 2012)
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is ...
Tesis Doctoral
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Molecular bases of proliferative heterogeneity in Saccharomyces cerevisiae
(2023-05-11)
Proliferative heterogeneity has been widely described in clonal cultures, but the mechanisms underlying this phenomenon are still poorly understood. On another hand, cell cycle regulation is tightly linked to proliferative ...