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PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
(MDPI, 2020)
Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination with chemotherapy, followed by adjuvant chemotherapy. ...
Tesis Doctoral
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Papel de factores de la transcripción y la replicación del ADN en el origen de la inestabilidad genómica.
(2017-09-25)
Mantener la integridad del genoma no es tarea fácil para las células. El ADN sufre constantes ataques de agentes químicos y/o físicos de origen exógeno y endógeno, pero no sólo eso, los propios procesos celulares que emplean ...
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Artículo
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Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation
(Oxford University Press, 2022)
During translation, nascent polypeptide chains travel from the peptidyl transferase center through the nascent polypeptide exit tunnel (NPET) to emerge from 60S subunits. The NPET includes portions of five of the six ...
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Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
(Frontiers Media S.A., 2021)
Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane ...
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The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Ribosome synthesis is a complex process that involves a large set of protein trans-acting factors, among them DEx(D/H)-box helicases. These are enzymes that carry out remodelling activities onto RNAs by hydrolysing ATP. ...
Tesis Doctoral
Tesis Doctoral
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Transcriptional regulation in Salmonella enterica by the Lysr-type factor LeuO
(2015-02-04)
En Salmonella enterica serovar Typhimurium, igual que en el resto de procariotas, el cromosoma se encuentra compactado en una región del citoplasma denominada nucleoide. Esta compactación es debida, en parte, a la presencia ...
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Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts
(Frontiers Media, 2017)
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the ...
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The role of chromatin at transcription-replication conflicts as a genome safeguard
(Portland Press, 2021)
DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the offspring. However, obstacles to replication fork (RF) progression cause RF stalling and compromise ...