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Artículo
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Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline
(American Society for Microbiology, 1992)
In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog a-amino-13-hydroxynor ...
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Ubiquitin and Ubiquitin-Like Proteins and Domains in Ribosome Production and Function: Chance or Necessity?
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Ubiquitin is a small protein that is highly conserved throughout eukaryotes. It operates as a reversible post-translational modifier through a process known as ubiquitination, which involves the addition of one or several ...
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Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
(BioMed Central, 2017)
Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic ...
Artículo
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Calmodulin in Paramecium: Focus on Genomic Data
(MDPI, 2022)
Calcium (Ca2+) is a universal second messenger that plays a key role in cellular signaling. However, Ca2+ signals are transduced with the help of Ca2+-binding proteins, which serve as sensors, transducers, and elicitors. ...
Tesis Doctoral
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Mejora de cepas de saccharomyces cerevisiae utilizables en la elaboracion de vinos de Jerez
(2000-08-03)
Los estudios encaminados a la mejora de los vinos de Jerez se han centrado fundamentalmente en la selección y mejora de la variedad de uva empleada, así como en un control fisico-quimico de la fermentación, y son pocos los ...
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A portable epigenetic switch for bistable gene expression in bacteria
(Nature Research, 2019)
We describe a portable epigenetic switch based on opvAB, a Salmonella enterica operon that undergoes bistable expression under DNA methylation control. A DNA fragment containing the opvAB promoter and the opvAB upstream ...
Artículo
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WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)
Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disorder, yet the ...
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Adaptation of Salmonella enterica to bile: essential role of AcrAB-mediated efflux
(Society for Applied Microbiology, 2018)
Adaptation to bile is the ability to endure the lethal effects of bile salts after growth on sublethal concentrations. Surveys of adaptation to bile in Salmonella enterica ser. Tyhimurium reveal that active efflux is ...
Artículo
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Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
(Nature Publishing Group, 2017)
Linker histone H1 is an important structural component of chromatin that stabilizes the nucleosome and compacts the nucleofilament into higher-order structures. The biology of histone H1 remains, however, poorly understood. ...
Artículo
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CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway
(Springer Nature, 2022)
The RNA world is changing our views about sensing and resolution of DNA damage. Here, we develop single-molecule DNA/RNA analysis approaches to visualize how nascent RNA facilitates the repair of DNA double-strand breaks ...