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Tesis Doctoral
Análisis estructural y funcional del elemento de inserción IS200
(1996)
El descubrimiento de las secuencias de inserción bacterianas y de su capacidad de modificar la expresión génica, movilizar genes y promover reorganizaciones cromosómicas ha supuesto una importante contribución para acabar ...
Tesis Doctoral
Biosíntesis de apocarotenoides en phycomyces blakesleeanus
(2013-03-22)
Phycomyces blakesleeanus se reproduce de forma vegetativa por esporas y sexual por micelios de sexo opuesto. El ciclo sexual se caracteriza porque las hifas desarrollan cigóforos, primeras estructuras sexuales, e incrementan ...
Artículo
Dynamics of the putative RNA helicase spb4 during ribosome assembly insaccharomyces cerevisiae
(American Society for Microbiology, 2011)
Spb4 is a putative ATP-dependent RNA helicase that is required for proper processing of 27SB pre-rRNAs and therefore for 60S ribosomal subunit biogenesis. To define the timing of association of this protein with preribosomal ...
Tesis Doctoral
Regulation of TDP2 function by sumo interactions.
(2017-09-29)
Topoisomerase 2 (TOP2) performs a vital enzymatic activity, solving DNA topological problems in fundamental metabolic processes. The enzyme is able to untangle DNA by passing an intact helix through a transient double-strand ...
Artículo
Identification of an extradiol dioxygenase involved in tetralin biodegradation: Gene sequence analysis and purification and characterization of the gene product
(American Society for Microbiology, 2000-02)
A genomic region involved in tetralin biodegradation was recently identified in Sphingomonas strain TFA. We have cloned and sequenced from this region a gene designated thnC, which codes for an extradiol dioxygenase required ...
Artículo
Placeholder factors in ribosome biogenesis: please, pave my way
(Shared Science Publishers, 2017)
The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm. In the nucleolus, precursor rRNAs associate with a ...
Artículo
Genetic Mining of Newly Isolated Salmophages for Phage Therapy
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Salmonella enterica, a Gram-negative zoonotic bacterium, is mainly a food-borne pathogen and the main cause of diarrhea in humans worldwide. The main reservoirs are found in poultry farms, but they are also found in wild ...
Tesis Doctoral
Genetic and molecular analysis of the salmonella effector SrfJ and use of type III secretion effectors as carriers for heterologous vaccine design.
(2018-10-29)
Salmonella enterica is a species of bacterial pathogens that can produce different diseases from gastroenteritis to typhoid fever. Salmonella possesses two different virulence-related type III secretion systems (T3SSs) ...
Tesis Doctoral
Artículo
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
(Oxford University Press, 2015)
Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC ...