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Artículo
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Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis
(Natural Research, 2018)
Salmonella enterica pathogenicity island 1 (SPI-1) is a gene cluster that encodes a type III secretion system and effectors involved in epithelial cell invasion. SPI-1 undergoes bistable expression, with concomitant formation ...
Artículo
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed ...
Artículo
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ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection
(Public Library of Science, 2020)
During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection is activated, the break will be channeled through homologous recombination; if not, it will be ...
Tesis Doctoral
Artículo
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Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae
(Oxford University Press, 1999)
Several mutants (spb1-spb7) have been previously identified as cold-sensitive extragenic suppressors of loss-of-function mutations in the poly(A)+-binding protein 1 of Saccharomyces cerevisiae. Cloning, sequence and ...
Tesis Doctoral
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Regulación de la asimilación de nitrato y de la fijación de nitrógeno en Azotobacter chroococcum
(1994)
Azotobacter chroococcum se caracteriza por su capacidad de utilizar distintas fuentes de nitrógeno, lo que le obliga a regular fuertemente la asimilación de los distintos compuestos nitrogenados. En este trabajo se ha ...
Artículo
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Contribution of phenotypic heterogeneity to adaptive antibiotic resistance
(2014)
Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after ...
Artículo
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Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function
(American Society for Microbiology, 2012)
Ribosomal proteins play important roles in ribosome biogenesis and function. Here, we study the evolutionarily conserved L26 inSaccharomyces cerevisiae, which assembles into pre-60S ribosomal particles in the nucle(ol)us. ...
Artículo
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Hybrid in silico/in vitro target fishing to assign function to “orphan” compounds of food origin – The case of the fungal metabolite atromentin
(Elsevier, 2019)
Many small molecules of food origin may effect human health but lack an adequate description of their biological activity. To fill this knowledge gap, a first-line workflow is needed to assign putative functions, rank the ...
Tesis Doctoral
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Molecular basis of Aicardi-Goutières syndrome
(2023-09-21)
DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous damage. One of the most dangerous injuries in DNA are doublestrand breaks. There are two main ...