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Artículo
Analysis of Salmonella lineage-specific traits upon cell sorting
(Frontiers Media SA, 2023-03-29)
Microbial cell individuality is receiving increasing interest in the scientific community. Individual cells within clonal populations exhibit noticeable phenotypic heterogeneity. The advent of fluorescent protein technology ...
Artículo
Artículo
The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes
(Oxford University Press, 2015)
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given the importance of this process in proliferating cells, it is obvious that understanding the ...
Artículo
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
(National Academy of Sciences, 2017)
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic ...
Tesis Doctoral
Genetic and molecular analysis of the virulence plasmid of Salmonella enterica serovar Typhimurium
(2010)
Salmonella enterica serovar Typhimurium posee un plásmido de gran tamaño (93 Kb) llamado plásmido de virulencia o pSLT. Dicho plásmido contiene el locus spv, esencial para la infección sistémica en roedores. El plásmido ...
Artículo
Nucleosome-mediated synergism between transcription factors on the mouse mammary tumor virus promoter
(National Academy of Sciences, 1997)
In unstimulated mammalian cells and in Saccharomyces cerevisiae, the mouse mammary tumor virus (MMTV) promoter is silent and organized into positioned nucleosomes, one of which encompasses the binding sites for glucocorticoid ...
Artículo
R-Loop–Mediated ssDNA Breaks Accumulate following Short-Term Exposure to the HDAC Inhibitor Romidepsin
(American Association for Cancer Research, 2021)
Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite regulatory approvals in hematological malignancies, limited solid tumor clinical activity has constrained ...
Tesis Doctoral
Artículo
The Structure of the SlrP-hTrx1 Complex Sheds Light on the Autoinhibition Mechanism of the Type-III Secretion System Effectors of the NEL Family
(Portland Press, 2014-11-15)
Salmonella infections are a leading cause of bacterial foodborne illness in the United States and the European Union. Antimicrobial therapy is often administered to treat the infection but increasing isolates are being ...
Artículo
New findings of Neurospora in Europe and comparisons of diversity in temperate climates on continental scales
(Allen Press Inc, 2006)
The life cycles of the conidiating species of Neurospora are adapted to respond to fire, which is reflected in their natural history. Neurospora is found commonly on burned vegetation from the tropic and subtropical regions ...