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Transcriptional regulation by the velvet protein VE-1 during asexual development in the fungus neurospora crassa.
(American Society for Microbiology, 2022)
Asexual reproduction in fungi facilitates the dispersal and colonization of new substrates and, in pathogenic fungi, allows infection of plants and animals. The velvet complex is a fungus-specific protein complex that ...
Artículo
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Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ...
Artículo
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Conidiation in Neurospora crassa: vegetative reproduction by a model fungus
(Springer, 2019)
Asexual development, conidiation, in the filamentous fungus Neurospora crassa is a simple developmental process that starts with the growth of aerial hyphae. Then, the formation of constrictions and subsequent maturation ...
Tesis Doctoral
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Mecanismos que regulan la salida de mitosis para el control de la correcta ploidía celular
(2021-01-20)
Durante la división celular es fundamental asegurar el correcto reparto del material genético entre las células hijas resultantes. Errores en este proceso pueden dar lugar a problemas como la aneuploidía, una condición en ...
Artículo
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CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells
(Elsevier, 2017)
Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). All reprogramming methods are accompanied by the induction of DNA damage, of which double-strand ...
Artículo
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Pseudomonas syringae Differentiates into Phenotypically Distinct Subpopulations During Colonization of a Plant Host
(Wiley-Blackwell, 2016)
Bacterial microcolonies with heterogeneous sizes are formed during colonization of Phaseolus vulgaris by Pseudomonas syringae. Heterogeneous expression of structural and regulatory components of the P. syringae type III ...
Artículo
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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have ...
Tesis Doctoral
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Apocarotenoides de los hongos mucorales.
(2014-01-13)
La interacción sexual y la producción de caroteno en hongos mucorales son procesos complejos de comunicación y regulación celular mediados por apocarotenoides y explotados por la industria. Esta tesis estudia la diversidad ...
Tesis Doctoral
Artículo
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Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
(Nature Publishing Group, 2018)
BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely ...