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Artículo
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
(Oxford University Press, 2012)
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe ...
Tesis Doctoral
Artículo
Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery
(Rockefeller University Press, 2009)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in mammalian cells, binds the tumor suppressor protein BRCA2. Here, we describe a new function for yeast ...
Artículo
Draft genome sequence of methanobacterium formicicum DSM 3637, an archaebacterium isolated from the methane producer amoeba pelomyxa palustris
(American Society for Microbiology, 2012)
Here is reported the draft genome sequence of Methanobacterium formicicum DSM 3637, which was isolated from the methane- producing amoeba Pelomyxa palustris. This bacterium was determined to be an endosymbiont living in ...
Artículo
Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans
(American Society for Microbiology, 2000)
The clustered prnB, prnC, and prnD genes are repressed by the simultaneous presence of glucose and ammonium. A derepressed mutation inactivating a CreA-binding site acts in cis only on the permease gene (prnB) while ...
Artículo
The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits
(Oxford University Press, 2016)
The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is ...
Tesis Doctoral
Regulation of DNA end resection by cell stemness
(2020-01-20)
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic applications, however, acquired genomic instability is one of the major concerns for its clinical use. The ...
Capítulo de Libro
Un ciclo de mejora docente para estudiar Evolución Molecular
(Universidad de Sevilla, 2022)
En asignaturas de genética, aprender a resolver problemas es esencial para fortalecer la integración de los conceptos que se imparten en las clases teóricas. De hecho, el modelo metodológico tradicional suele basarse en ...
Artículo
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop ...
Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One important player in this interface is the poly(A) + -RNA– binding protein Nab2, which ...