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Artículo
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SrfJ, a salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.
(American Society for Microbiology, 2012)
Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we ...
Artículo
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Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections
(American Society for Microbiology, 2015-12)
Viruses of the Enterovirus genus of picornaviruses, including poliovirus, coxsackievirus B3 (CVB3), and human rhinovirus, commandeer the functions of host cell proteins to aid in the replication of their small viral genomic ...
Artículo
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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
(Cell Press, 2015)
Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences of its accumulation are unclear. Here we show that endogenous ...
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Dormant intracellular salmonella enterica serovar typhimurium discriminates among salmonella pathogenicity island 2 effectors to persist inside fibroblasts
(American Society for Microbiology, 2014-01)
Salmonella enterica uses effector proteins delivered by type III secretion systems (TTSS) to colonize eukaryotic cells. Recent in vivo studies have shown that intracellular bacteria activate the TTSS encoded by Salmonella ...
Artículo
Tesis Doctoral
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Búsqueda de nuevos reguladores de salida de mitosis: Hit1 y su papel en el control del ciclo celular
(2017-09-18)
El ciclo celular es un conjunto ordenado de sucesos que conducen a la duplicación celular, y constituye un proceso altamente regulado, en el que la progresión entre las distintas fases que lo constituyen es promovida por ...
Tesis Doctoral
Artículo
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Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin
(MDPI, 2014)
Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated ...
Artículo
Artículo
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MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy
(Impact Journals, 2018)
Rectal cancer represents approximately 10% of cancers worldwide. Preoperative chemoradiotherapy increases complete pathologic response and local control, although it offers a poor advantage in survivorship and sphincter ...