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Artículo
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Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres
(Public Library of Science, 2013)
When chromosomal DNA is damaged, progression through the cell cycle is halted to provide the cells with time to repair the genetic material before it is distributed between the mother and daughter cells. In Saccharomyces ...
Artículo
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C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
(The Company of Biologists, 2021)
Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is a conserved eukaryotic protein complex with a key role in mRNP biogenesis and maturation that prevents ...
Tesis Doctoral
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Expression patterns and interstrain variation in LexA-‐regulated genes of Salmonella enterica serovar Typhimurium
(2020-12-21)
Los serovares Typhimurium y Enteritidis de Salmonella enterica son responsables de la mayoría de las infecciones no tifoideas de Salmonella en humanos. En la mayor parte del trabajo de investigación llevado a cabo sobre ...
Artículo
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Comparative transcriptomic analysis unveils interactions between the regulatory CarS protein and light response in Fusarium
(BMC, 2019)
Background The orange pigmentation of the agar cultures of many Fusarium species is due to the production of carotenoids, terpenoid pigments whose synthesis is stimulated by light. The genes of the carotenoid pathway and ...
Artículo
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High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast
(Public Library of Science, 2016)
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH complex involved in both nucleotide excision repair (NER) and transcription. Some mutant alleles of ...
Tesis Doctoral
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Una aproximación genómica a la regulación por la luz de la transcripción en Phycomyces blakesleeanus
(2012)
En esta Tesis Doctoral describimos el efecto de la luz sobre la transcripción y la acumulación de proteínas en el hongo Phycomyces blakesleeanus. Phycomyces responde a muchos estímulos ambientales, entre ellos la luz. ... ...
Artículo
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The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
(Springer Nature, 2021)
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as ...
Artículo
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Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The tyrosine kinase inhibitor Sorafenib (Sfb) remains the globally accepted treatment for advanced HCC. ...
Tesis Doctoral
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Papel de la reducción de histonas en la protección de los telómeros durante la pre-senescencia
(2020-01-22)
Los telómeros son estructuras nucleoproteícas cuya función principal es evitar que los extremos de los cromosomas sean reconocidos como roturas en el ADN y sean procesados por las maquinarias de checkpoints y reparación, ...
Artículo
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OxyR-dependent formation of DNA methylation patterns in OpvABOFF and OpvABON cell lineages of Salmonella enterica
(Oxford University Press, 2015)
Phase variation of the Salmonella enterica opvAB operon generates a bacterial lineage with standard lipopolysaccharide structure (OpvABOFF) and a lineage with shorter O-antigen chains (OpvABON). Regulation of OpvAB lineage ...