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Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica
(Oxford University Press, 2020)
Expression of Salmonella enterica loci harboring undermethylated GATC sites at promoters or regulatory regions was monitored by single cell analysis. Cell-to-cell differences in expression were detected in ten such loci ...
Artículo
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The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes
(Public Library of Science, 2014)
The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation phenotypes). ...
Artículo
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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
(Elsevier, 2020)
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 ...
Artículo
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Regulation of igaA and the rcs system by the mvia response regulator in salmonella enterica
(American Society for Microbiology, 2009)
IgaA is a membrane protein that prevents overactivation of the Rcs regulatory system in enteric bacteria. Here we provide evidence that igaA is the first gene in a 70-dependent operon of Salmonella enterica serovar Typhimurium ...
Tesis Doctoral
Artículo
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Mutational and non mutational adaptation of Salmonella enterica to the gall bladder
(Natural Research, 2019)
During systemic infection of susceptible hosts, Salmonella enterica colonizes the gall bladder, which contains lethal concentrations of bile salts. Recovery of Salmonella cells from the gall bladder of infected mice yields ...
Tesis Doctoral
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Estudio de la translocación al hospedador de los efectores PIPB2 y SSEK1 de salmonella enterica serovar typhimurium y análisis genético de SSEK1
(2016-10-21)
Salmonella enterica es una especie de bacteria patógena Gram negativa responsable de diversas enfermedades en animales como la gastroenteritis y la fiebre tifoidea. S. enterica expresa dos sistemas de secreción tipo III ...
Artículo
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Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.
(Nature Research, 2023)
Bacterial biofilms are surface-attached communities that are difficult to eradicate due to a high tolerance to antimicrobial agents. The use of non-biocidal surface-active compounds to prevent the initial adhesion and ...
Tesis Doctoral
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Genética y fisiología de la resistencia a nicomicina en "Phycomyces"
(1989)
Entre los componentes de la pared celular de Phycomyces la quitina destaca como polímero estructural mayoritario. Para comprender su mecanismo de síntesis se han aislado mutantes resistentes a nicomicina, inhibidor por ...
Artículo
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The Role of Replication-Associated Repair Factors on R-Loops
(MDPI, 2017)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication ...