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Tesis Doctoral
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Regulation of DNA end resection by cell stemness
(2020-01-20)
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic applications, however, acquired genomic instability is one of the major concerns for its clinical use. The ...
Capítulo de Libro
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Un ciclo de mejora docente para estudiar Evolución Molecular
(Universidad de Sevilla, 2022)
En asignaturas de genética, aprender a resolver problemas es esencial para fortalecer la integración de los conceptos que se imparten en las clases teóricas. De hecho, el modelo metodológico tradicional suele basarse en ...
Artículo
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop ...
Artículo
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XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
(MDPI, 2022)
Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution eukaryotic cells have evolved a chemically reversible modification of the cytosine base. These dynamic ...
Artículo
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Transcriptional regulation by the velvet protein VE-1 during asexual development in the fungus neurospora crassa.
(American Society for Microbiology, 2022)
Asexual reproduction in fungi facilitates the dispersal and colonization of new substrates and, in pathogenic fungi, allows infection of plants and animals. The velvet complex is a fungus-specific protein complex that ...
Artículo
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Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ...
Tesis Doctoral
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Mecanismos que regulan la salida de mitosis para el control de la correcta ploidía celular
(2021-01-20)
Durante la división celular es fundamental asegurar el correcto reparto del material genético entre las células hijas resultantes. Errores en este proceso pueden dar lugar a problemas como la aneuploidía, una condición en ...
Artículo
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Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development
(BMC, 2022)
Background After embryonic development, Caenorhabditis elegans progress through for larval stages, each of them finishing with molting. The repetitive nature of C. elegans postembryonic development is considered an ...
Tesis Doctoral
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The influence of chromatin in DNA-RNA hybrid metabolism
(2020-07-07)
El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, existen situaciones que comprometen la estabilidad del genoma dando lugar a la aparición de ...
Artículo
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Analysis of Salmonella lineage-specific traits upon cell sorting
(Frontiers Media SA, 2023-03-29)
Microbial cell individuality is receiving increasing interest in the scientific community. Individual cells within clonal populations exhibit noticeable phenotypic heterogeneity. The advent of fluorescent protein technology ...