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Tesis Doctoral
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Papel de la reducción de histonas en la protección de los telómeros durante la pre-senescencia
(2020-01-22)
Los telómeros son estructuras nucleoproteícas cuya función principal es evitar que los extremos de los cromosomas sean reconocidos como roturas en el ADN y sean procesados por las maquinarias de checkpoints y reparación, ...
Artículo
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Special Issue: Type III Secretion Systems in Human/Animal Pathogenic Bacteria
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Artículo
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Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
(Rockefeller University Press, 2022)
Membrane contact sites are functional nodes at which organelles reorganize metabolic pathways and adapt to changing cues. In Saccharomyces cerevisiae, the nuclear envelope subdomain surrounding the nucleolus, very plastic ...
Tesis Doctoral
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Identificación y análisis funcional del lnc-Nr6a1 y del mRNA Serpine1 como reguladores tempranos de la transición epitelio-mesénquima
(2022-05-12)
La transición epitelio-mesénquima (EMT) es un proceso por el que las células sufren un cambio fenotípico reversible, perdiendo las características epiteliales y adquiriendo atributos mesenquimales. Estos cambios implican ...
Artículo
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Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
(Frontiers Media, 2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle ...
Artículo
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Overexpression of budding yeast protein phosphatase Ppz1 impairs translation
(Elsevier, 2020)
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes only found in fungi. Ppz1 is regulated in vivo by two inhibitory subunits, Hal3 and Vhs3, which are ...
Artículo
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Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication forks. These responses rely ...
Artículo
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Transcription-driven DNA supercoiling counteracts H-NS-mediated gene silencing in bacterial chromatin.
(Nature Research, 2024-03-30)
In all living cells, genomic DNA is compacted through interactions with dedicated proteins and/or the formation of plectonemic coils. In bacteria, DNA compaction is achieved dynamically, coordinated with dense and ...
Artículo
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Enhanced Gene Regulation by Cooperation between mRNA Decay and Gene Transcription
(Elsevier, 2023)
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process from mRNA synthesis in the nucleus to translation and degradation in the cytoplasm, but works as a circular ...
Artículo
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Aging during C. elegans L1 quiescence
(Impact Journals LLC, 2020)