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Artículo
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Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica
(Oxford University Press, 2020)
Expression of Salmonella enterica loci harboring undermethylated GATC sites at promoters or regulatory regions was monitored by single cell analysis. Cell-to-cell differences in expression were detected in ten such loci ...
Artículo
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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
(Elsevier, 2020)
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 ...
Artículo
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Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.
(Nature Research, 2023)
Bacterial biofilms are surface-attached communities that are difficult to eradicate due to a high tolerance to antimicrobial agents. The use of non-biocidal surface-active compounds to prevent the initial adhesion and ...
Artículo
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Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Understanding which intracellular signaling pathways are activated by manganese stress is crucial to decipher how metal overload compromise cellular integrity. Here, we unveil a role for oxidative and cell wall stress ...
Artículo
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UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional ...
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Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
(Frontiers Media S.A., 2022)
Artículo
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Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
(Elsevier, 2021)
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. ...
Tesis Doctoral
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Identification and Characterization of Factors Involved in Sodium Selenite Toxicity
(2021-07-06)
Selenium (Se) is an essential micronutrient in many organisms. Despite being essential for some organisms, the range between its requirement and its toxicity is very narrow. Health benefits related to Se include the ...
Tesis Doctoral
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DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
(2021-10-28)
La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una célula a su descendencia. De hecho, evolutivamente, nuestras células han desarrollado numerosos procesos ...
Tesis Doctoral
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Crosstalk between DNA end resection and RNA metabolism
(2020-01-23)
DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to ...