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Mostrando ítems 161-169 de 169
Tesis Doctoral
Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
(2023-07-07)
Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de doble cadena del ADN (DSBs) la lesión más citotóxica para la célula. Numerosos estudios han mostrado ...
Artículo
Three Genes Involved in Different Signaling Pathways, carS, wcoA, and acyA, Participate in the Regulation of Fusarin Biosynthesis in Fusarium fujikuroi
(MDPI, 2024)
The phytopathogenic fungus Fusarium fujikuroi has a rich secondary metabolism which includes the synthesis of very different metabolites in response to diverse environmental cues, such as light or nitrogen. Here, we focused ...
Artículo
Rat1 promotes premature transcription termination at R-loops
(Oxford University Press, 2024-04-24)
Certain DNA sequences can adopt a non-B form in the genome that interfere with DNA-templated processes, including transcription. Among the sequences that are intrinsically difficult to transcribe are those that tend to ...
Tesis Doctoral
Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines
(2023-06-07)
El carcinoma hepatocellular (CHC) es reconocido como el principal cáncer primario de hígado y uno de los cánceres con mayor incidencia y mortalidad a nivel mundial. Éste se desarrolla en un contexto de enfermedad hepática ...
Tesis Doctoral
Role of regulatory proteins in carotenoid biosynthesis and metabolism in Fusarium fujikuroi
(2024-04-12)
La capacidad de los hongos filamentosos de adaptarse a cambios ambientales a cambios ambientales ha conducido al desarrollo de mecanismos sofisticados, como la producción de metabolitos secundarios que, a pesar de no ser ...
Artículo
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)
RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is specifically found in higher eukaryotes and associates with the elongating RNA polymerase II. To ...
Artículo
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer ...
Artículo
SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
(CELL PRESS (Elsevier), 2024)
During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication factors or nucleotides. A limited number of histone post-translational modifications at stalled RFs ...
Tesis Doctoral
Study of Pol5 protein from Saccharomyces cerevisiae and its human ortholog MYBBP1A in ribosome biogenesis
(2024-04-10)
Los ribosomas son los orgánulos celulares que llevan a cabo el llamado proceso de traducción, en el cual las proteínas se sintetizan utilizando la información codificada en los RNA mensajeros (mRNAs). Los ribosomas están ...