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Mostrando ítems 161-170 de 171
Artículo
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Bioavailability and provitamin A activity of neurosporaxanthin in mice
(Nature Publishing Group, 2023-10-20)
Various species of ascomycete fungi synthesize the carboxylic carotenoid neurosporaxanthin. The unique chemical structure of this xanthophyll reveals that: (1) Its carboxylic end and shorter length increase the polarity ...
Artículo
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Copy Number Heterogeneity in the Virulence Plasmid of Salmonella enterica
(Frontiers Media, 2020)
Quantitative PCR analysis shows that the virulence plasmid of Salmonella enterica serovar Typhimurium (pSLT) is a low-copy-number plasmid, with 1–2 copies per chromosome. However, fluorescence microscopy observation of ...
Tesis Doctoral
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Role of FACT and other chromatin-related factors in the origin of genetic instability
(2024-02-15)
El mantenimiento de la integridad del genoma es un requisito indispensable para garantizar el correcto funcionamiento de la célula, así como una transmisión fidedigna de la información genética a la descendencia. Las ...
Tesis Doctoral
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Transcriptional regulation by the Velvet complex during development in Neurospora crassa
(2023-04-21)
Developmental transitions in fungi are key to their success in colonizing new habitats and adapting to stressful environmental conditions. Developmental transitions are regulated by environmental factors such as light. ...
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Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are ...
Artículo
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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023-11-09)
DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 but can occasionally become abortive generating permanent protein-linked single strand breaks (SSBs). ...
Tesis Doctoral
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Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
(2023-07-07)
Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de doble cadena del ADN (DSBs) la lesión más citotóxica para la célula. Numerosos estudios han mostrado ...
Tesis Doctoral
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Identification and Characterization of Factors Involved in Sodium Selenite Toxicity
(2021-07-06)
Selenium (Se) is an essential micronutrient in many organisms. Despite being essential for some organisms, the range between its requirement and its toxicity is very narrow. Health benefits related to Se include the ...
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The RNAi Machinery in the Fungus Fusarium fujikuroi Is Not Very Active in Synthetic Medium and Is Related to Transposable Elements
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-05-16)
Small RNAS (sRNAs) participate in regulatory RNA interference (RNAi) mechanisms in a wide range of eukaryotic organisms, including fungi. The fungus Fusarium fujikuroi, a model for the study of secondary metabolism, contains ...
Artículo
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EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
(Oxford University Press, 2024-06-24)
DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to the accumulation of single-stranded DNA (ssDNA) that triggers the activation of the ATR checkpoint ...