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Tesis Doctoral
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Estudio de asimetrías asociadas al huso mitótico de Saccharomyces cerevisiae: nuevos reguladores del posicionamiento del huso y la herencia no aleatoria de los centros organizadores de microtúbulos
(2020-01-24)
La división celular asimétrica es un tipo particular de división en la que se generan dos células de distinto tamaño, contenido, función y/o destino. Este tipo de división es particularmente relevante durante los procesos ...
Artículo
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Fusarium photoreceptors
(MDPI, 2023-03-04)
Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic activity and their complex secondary metabolism. This includes the synthesis of carotenoids, whose ...
Artículo
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
(Cell Press, 2023-08-03)
To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To uncover genes that suppress DNA damage in human cells, we undertook flow-cytometry-based CRISPR-Cas9 ...
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Tesis Doctoral
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Non-canonical DNA structures in Double Strand Break repair
(2023-05-22)
DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell viability. To repair them, the cell has evolved two main alternative mechanisms, non-homologous ...
Tesis Doctoral
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Regulación y modificación de rutas biosintéticas de metabolitos con interés industrial en Fusarium fujikuroi
(2024-03-22)
Los hongos filamentosos han sido utilizados como organismos modelos para el estudio de diferentes procesos biológicos como la regulación por la luz y el ritmo circadiano, el control de la esporulación o las interacciones ...
Artículo
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Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
(Oxford University Press, 2020)
DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer ...
Artículo
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FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
(Springer Nature, 2022)
Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme hypersensitivity to interstrand crosslink (ICL) agents. Additionally, the FA ...